The Study About Improvement Of Ibuprofen Synthesis Process

Ibuprofen, whose chemical name is Isobutyl benzene acid, is NSAIDs (non-steroidal anti-inflammatory drugs), its efficacy than Aspirin better, less adverse reactions. Ibuprofen is one of the world’s best-selling non-prescription drugs, many reported about ibuprofen synthesis. The literature reports a variety of synthetic routes, but there are different disadvantages. The literatures report a variety of synthetic routes, but there are different disadvantages. The domestic manufacturers using traditional indexable rearrangement operating difficulties, higher cost, heavier pollution problems. BHC process route, most foreign manufacturers to adopt the most advanced green manufacturing process, with short steps, atom utilization, low pollution, but the technology is very difficult, and we have industrialized the process is completely different, if the switching this process, the original technology and equipment required to replace all the high input costs.In this paper, it details the research progress of ibuprofen synthesis method, and also it reviews the main advantages and disadvantages of each method, additionally improving the process we have industrialized——aryl-1,2-translocation rearrangement. Iso-butylbenzene, and2-chloropropionyl occur chloride Friedel-Crafts acylation reaction, changing the reaction temperature and time, canceling the solvent, and after the end of the reaction, the condensation reaction solvent is added. Meanwhile, it is catalyzed and ketalized with neopentylglycol using sulfuric acid instead of p-toluenesulfonic acid as a catalyst. I used single factor method to find the optimized process conditions, based on an experimental basis, and followed by validation of the pilot and pilot production. Besides, after the ketalation substrate conducted a research and analysis, it is certified that the text is made a breakthrough progress by using pentaerythritol instead of neopentyl glycol. Currently pilot scale test certificate is ongoing, and if applied to industrial production, the cost of ibuprofen production can be greatly reduced.The improved process avoids the use of more expensive p-toluenesulfonic acid and petroleum ether, which can easily form a byproduct. Then the reaction conditions are easy to control because of avoiding the traditional process using chilled brine below-5℃. Relative to p-toluenesulfonic acid, the concentrated sulfuric acid is cheaper and greatly reduces wastewater COD and pollutions. Also the improvements of acylation and ketal process increase capacity.After the process improvement, production of ibuprofen product quality was in line with the Chinese pHarmacopoeia, total yield increased and decreased costs were appeared. Such as calculating2-Chloropropanoyl chloride of the starting material, the total yield is increased from75.5%to77.7%and per ton of raw material costs decrease to50635.52RMB from54,740.95RMB. Because the operation is simplified, production capacity is improved and reducing energy consumption1869.82RMB.In summary, as soon as the ibuprofen synthesis process is improved, achieved the purpose of lower costs, reduced pollution, improved productivity, and increased social and economic benefit.