Synthesis And Characterization Of Functionalized Gold Nanoparticles With Continuous Changes In Surface Hydrophobicity

In recent years, with the rapid development of nanotechnology in energy, materials, environment, biomedical application and so on, it has made breakthrough progress. The nanometer material is widely used and it makes human contact more and more closely, and the related research of nanometer materials has become the world’s most popular one of the subject. In many nanometer materials with different composition, shapes and sizes, gold nanoparticles get the favored of scientists because of they are easy to synthesis, stable, dispersive and biocompatible. Therefore, the construction of different function of gold nanoparticles at present is one of the important research direction in biomedical fields.In order to construct the surface hydrophobicity continuous variation of the gold nanoparticles, we first designed and synthesized a series of ligands compounds, which containing sulfur atoms as the group, and having different hydrophilic-hydrophobic properties. And then adjusting the ratio of hydrophilic/hydrophobic molecules covalent connected to the proportion of the gold nanoparticles surface, we make the function of gold nanoparticles in hydrophobicity continuous change, and make use of oil and water distribution coefficient for the determination of the hydrophobic characterized quantitatively.This topic in the preparation of functional gold nanoparticles process, tried a variety of synthetic route, and through the science of screening, found the best route and conditions, got more uniform, radius smaller gold nanoparticles. In the next characterization of the physical and chemical properties characterization,the synthesis method got proof and analysis and we put forward the reasonable interpretation and explanation. After optimization of synthetic route, by changing the types of ligands, even choosing the right drug molecules, connected to the preparation of the gold nanoparticles, we found a new type of drug synthesis method, which can be applied to production practice.The published literature has never been reported the way of oil and water distribution coefficient to characterize nanometer materials hydrophobic. Gold nanoparticles determination of oil and water distribution coefficient of this topic is a kind of innovation. As for chemical modification of small molecules functionalized gold nanoparticles surface ligands number of determination, and there were no more precise method, it is only by transmission electron microscopy and nitrogen element analysis to get the average value. This subject adopts the molecular weight and the method of combining the density, calculates the average number of gold nanoparticles and the number of ligand distribution. This calculation method although remains to be developed, but it is feasible.This topic through the screening appropriate ligands and exploring the new synthesis method, synthesize and character gold nanoparticles with continuous changes of hydrophobicity.