| Gold nanoparticles have stimulated intense research over the past decade due to the large surface area, high surface energy, and quantum size effect of nanomaterials. The anisotropic gold nanoparticles have some particular natures compared with the spherical gold nanoparticles. There are many researches about the synthesis of anisotropic gold nanoparticles such as the clubbed, triangle and polygon. However, the synthesis of networked gold nanoparticles and it’s applications in the analysis was rarely. The main reason was the back-to-back studies between materials science and analytical chemistry. Moreover, their future applications in multipurpose analytical devices require an in-depth study in view of selectivity. The main content of research is as follow:(1) Report a novel approach for preparation of networked gold nanoparticles using reactive oxygen species as a novel reducing agent, along with nonionic fluorosurfactant assistance. The formation mechanism of the networked AuNPs is demonstrated by transmission electron microscopy, high-resolution transmission electron microscopy, UV-visible spectroscopy, powder X-ray diffraction measurement and energy dispersive X-ray spectroscopy. Finally, the networked AuNPs have been applied for ultrasensitive detection of aminothiols in human urine and plasma samples(2) We have demonstrated the suitability of fluorosurfactant-capped spherical gold nanoparticles as HPLC postcolumn colorimetric reagents for the direct assay of cysteine, homocysteine, cystine, and homocystine. The success of this work was based on the use of an on-line tris(2-carboxyethyl)phosphine reduction column for cystine and homocystine. Several parameters affecting the separation efficiency and the postcolumn colorimetric detection were thoroughly investigated. Under the optimized conditions, cysteine, homocysteine, cystine, and homocystine in human urine and plasma samples were determined. This proposed method was rapid, inexpensive, and simple. |
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