| Chapter1:This part summarized the properties, preparation, modification, characterization devices and applications of Fe3O4magnetic nanoparticles. The structure and properties of cyclodextrin and its derivatives were depicted briefly. The preparation and application of cyclodextrin and its derivatives modified Fe3O4magnetic nanoparticles were reviewed in detail.Chapter2:The Fe3O4magnetic nanoparticles (MNPs) were prepared by the co-precipitation method in the alkaline solution. β-cyclodextrin (β-CD) modified magnetic nano-composites (β-CD-MNPs) was fabricated by the combination of3-aminopropyl triethoxysilane coated magnetic Fe3O4nanoparticles (APTES-MNPs) with6-O-toluenesulfonyl-β-cyclodextrin (6-TsO-β-CD). The β-CD-MNPs grafting was confirmed by TEM, XRD, DLS, FTIR, TGA and VSM (vibrating sample magnetometer). The core size of Fe3O4magnetic nanoparticles and its nano-composites was14nm determinated by TEM. The average MNPs core sizes evaluated from the XRD patterns by using Scherrer’s equation was20.6nm, consistent with that observed from the TEM image. The number of β-CD molecules immobilized on each β-CD-MNPs being calculated was about165. The obtained magnetic nanoparticles and nano-composites turned out to be superparamagnetic with a relatively high saturation magnetization value of60emu/g and44emu/g, respectively.Chapter3:The adsorption behavior of β-cyclodextrin modified magnetic nano-composites (β-CD-MNPs) was demonstrated using methylene blue (MB) as the model compound by UV spectrophotometry. The data revealed that the equilibrium equations fitted well with the Langmuir model: consistent with the monolayer adsorption process. The maximum inclusion capacity of the β-CD-MNPs for MB was78.4mg/g at T=25℃, reaction time=1h and pH=8. Chapter4: A glassy carbon electrode (GCE) was first modified with P-cyclodextrin functionalized Fe3O4magnetic nanoparticles (β-CD-MNPs). Electrochemical behaviors of tryptophan (Trp) at the β-CD-MNPs modified electrode were confirmed by cyclic voltammetry (CV). Some parameters including pH of electrolyte, the amount of β-CD-MNPs and scan rate of voltammetric sweeping segments have been optimized. Under the optimum conditions, the oxidation peak current displayed a calibration response for Trp over a wide concentration range from8.0×10-7to3.0×10-4M with a detection limit of5.0×10-7M (S/N=3). The response of modified electrode to Trp exhibited a good analytical performance to the interferents comparable with unmodified electrode. The proposed procedure was successfully applied to the determination of Trp in a commercial amino acid injection.Chapter5: Carboxymethyl-β-cyclodextrin and dimethyl-β-cyclodextrin modified magnetic nano-composites (CM-β-CD-MNPs, DM-β-CD-MNPs) were fabricated by layer-by-layer method and characterized by FTIR. The obtained nano-composites (β-CD-MNPs, CM-β-CD-MNPs and DM-β-CD-MNPs) turned out to be superparamagnetic with a relatively high saturation magnetization value of44emu/g,47emu/g and46emu/g, respectively. The solubility of magnetic nanoparticle and nano-composites were determined by saturated water solution method, The CM-β-CD-MNPs was eutectic with the solubility is7.02mg/mL. The inclusion behavior of magnetic nano-composites was demonstrated using ketoprofen as the model drug by UV spectrophotometry, the inclusion capability order was CM-β-CD-MNPs>β-CD-MNPs>DM-β-CD-MNPs in the neutral solution. The ketoprofen/magnetic nano-composites complexes were prepared by ultrasonic method. The release of ketoprofen from the nano-composites was investigated in the phosphate buffer at pH7.0and310K. It is found that ketoprofen/CM-β-CD-MNPs complex showed a rapid release up to75%release rate in initial60min and then reaches a steady release. Chapter6:This part summarized the inclusion behaviour of β-cyclodextrin modified magnetic nano-composites and guest molecular. The prepared nano-composites could be applied in other fields with the magnetic properties of Fe3O4nanoparticles and host-guest inclusion effect of β-CD. |
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