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Chemical Constituents Of Three Endophytes

Posted on:2014-01-19Degree:MasterType:Thesis
Country:ChinaCandidate:Y JiaoFull Text:PDF
GTID:2230330398959161Subject:Natural medicinal chemistry
Abstract/Summary:PDF Full Text Request
An endophyte is a bacterial (including actinomycete) or fungal microorganism, which spends the whole or part of its life cycle colonizing inter-and/or intra-cellularly inside the healthy tissues, typically causing no apparent symptoms of disease. Since their chemically novel and bioactive metabolites, and the important role in the defense strategy of the host, endophytic fungi have been warmly concerned. However, endophytes in some special species, such as bryophyte and lichen, are often overlooked. Research on these endophytes becomes necessary. Therefore, as a significant reservoir of genetic diversity, they could become an important source of bioactive, and chemically novel compounds, and provide more evidence to study their function in the host.In this paper, one endophytic fungus from liverwort and two endolichenic fungal strains were subjected to be fermented for chemical investigation.40compounds were isolated, and14of them were new compounds, including5terphenylquinones,2polyketones,3sesquiterpenoids,3coumarins, and1funicone derivative. The structures of these new compounds were elucidated by spectroscopic data, with the help of octant rule and TDDFT CD calculations. Allelopathic and antifungal activities test of some of the isolated compounds showed that compound2exhibited significant allelopathic activity, while compound31showed moderate antifungal activity.
Keywords/Search Tags:Endop, Secondary metabolite, Terphenylqiunone, Sesquiterpenoid, Bioactivity
PDF Full Text Request
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