Modeling And Analysis Of The Mammalian Cell Cycle Regulatory Network

Accurate regulation of the cell cycle is very important to biological survival, reproduction, development and genetic. In the evolutionary process, the cell cycle regulatory network has evolved into a very clever system, which just pays as little as possible for risk aspects to ensure the robustness, rapidity and accuracy of cell division. In order to understand the internal control details of the system, a mammalian cell cycle model, which is easy to analyze and control, is established based on the control mechanism. After making an assay of the parameters, the parameters are matched and the model is simulated.In addition, a variety of human diseases, particularly the tumor and cancer, is related to cell cycle. Cancer cells, which preserve the ability of division, come into being, when normal cells suffer mutations or deletions in some functional modules. Researching on cancer cells contributes to a more intuitive understanding of cell division. Therefore, the mammalian cell cycle model is simplified according to the mechanism of cancer lesions. Then the robustness of the simplified model is analyzed in order to get the condition of changing its robustness. After verifying the condition in the complete model, finally, we got the possibly methods to stop the cancer cells dividing while normal mitotic cells continue to divide, and pointed out the possibility of cancer gene therapy.Finally, the cell cycle network’s control strategy, that the control mechanisms of the robustness, is analyzed from a macro perspective. Pave the way for designing a new system, which can be self-regulation and is powerful enough in robustness, rapidity and accuracy.