| Interleukin is a group with mediates leukocyte interactions among cytokines, in theimmune system play an important physiological function. Yi is now officially named to theIL-23。In1976, Morgrn[1] was first discovered in mitogen-stimulated lymphocyte culturesupernatants or conditioned medium (Conditional medium, CM) in the presence of acytokine, he is able to selectively maintain T lymphocytes in vitro long-term growth, it will bethe factor known as T cell growth factor (T cell growth factor, TCGF)。Switzerland in1979at the second International Conference on lymphatic factor, expertsshall contact leukocyte interaction factor are collectively referred to as interleukin(Interleukin, IL); there will be activated T cells produced by lymphocytes, in betweeninteracting factors, namely to TCGF called white cells interleukin-2(Interleukin-2, IL-2)[2].Interleukin is a very important family of cytokines, which in the maturation of immune cells,activation, proliferation and immune regulation in a series of processes such as both play animportant role, and that they are involved in many physiological and pathological responses。Interleukin-2(IL-2) is an immune response to the core material, is composed of Tlymphocytes (especially CD4+T cells) secretion of a glycoprotein, is a kind of polypeptidedrugs, also known as T cell growth factor, is currently the preferred antineoplastic drugs。With the deepening of the research, especially in1983gene engineering (recombinant)the appearance of IL-2, make IL-2research has made greater progress. It is found that IL-2besides acting on T cells, can also be applied to a variety of immune effector cells, includingB cells, macrophages, and NK cells. Stimulation can produce antibodies against theproliferation of B cells and can induce novel killer cell lymphokine activated killer cell(LAK)。Interleukin-2in immune response plays an important role, is a kind of immunityintensifier, anti-virus, anti-tumor and improve and enhance the immune function of organism.Can enhance the body of viruses, bacteria, protozoa and other immune responses to infection, clearance in vivo tumor cells and virus-infected cells. It can improve antibody and interferongamma secretion, can stimulate the production of IFNγ and TNF-α,β; stimulate Thproliferation and activation; activation of neutrophils; stimulation of NK and tumor invasion(TIL) on proliferation of lymphocytes. At present, IL-2has been applied to the treatment oftumor, AIDS and infectious diseases, and has achieved significant results. |
