Study On The Construction Of Visible Representation System Of Human Brain Antamic Knowledge Based On 3D Geometric Model

Human brain is the most complicated structure and organ in human body. Integration of human brain knowledge in all aspects, including morphology, structure, function and physiology, etc., to form a comprehensive knowledge platform, is of great significance in anatomical teaching, functional study and clinical treatment of human brain.In this study, a digital human brain model was built up with the use of the cross-section slice images of human brain selected from the first female Chinese Visible Human dataset (CVH-2), the study emphasis was put on the linking and representation method among different domain knowledge, especially between morphological data (2D slice images, 3D geometric model) and anatomic knowledge, so that the visible representation of human brain anatomic knowledge based on the 3D geometric model could be accomplished. The concrete procedure is as follows, the 3D geometric model of human brain was built up with Discrete Marching Cubes and Ray-casting composition algorithms, and the"part of"relation-based organ level anatomic knowledge database was initially established by adopting means of ontology technology in artificial intelligence field and drawing on the construction rules of Digital Anatomist Foundational Model of Anatomy (FMA). Then, the coordinates transformation formula was investigated between 3D coordinates of actors in 3D scene and 2D coordinates of corresponding pixels in 2D slice image by analyzing the nature of volume data field constructed from 2D successive cross-section images, and the mapping mechanisms among the 3D geometric model and anatomy knowledge, 2D slice image were studied. As a result, their synchronous visible representation was reached with the help of callback function mechanism. Furthermore, to achieve deeply observation and anatomic knowledge acquisition in the inner part of 3D geometric model, a 3D Widget was constructed based on the Observe/Command design pattern. The 3D geometric model can be cut interactively using this Widget. Extraction in an arbitrary direction and exploration in the normal of virtual slice images was also implemented by combing a cutting coordinate system and a spatial relation and moving model between a plane and a rectangular. This method effectively solved the deficiency of MR which would produce slice images along fixed direction, and satisfy the clinical inspection from arbitary direction and angles. Finally, a system for visible representation of human brain knowledge was developed in Visual C++ 6.0 and VTK5.0 software.In conclusion, a meaningful investigation was taken on the integration and synchronous visible representation methods of 3D geometric model, 2D slice images and symbolic anatomic knowledge, the established visible representation system of human brain anatomic knowledge which characterized by the powerful interactive functions and the synchronous demonstration of 3D model, 2D slice images and anatomic knowledge, has successfully pass the examination and approval of experts, and its function satisfy the requirement of digital anatomical teaching of human brain. The research results would provide helpful references and successful experiences for further integration of human brain knowledge in other aspects, and the method can also be extensively applied to other human organs and tissues.