Design And Synthesis Of Triazole Derivates

Fungal infections have been recognized as a major cause of morbidity and mortality during the last few decades. In this thesis, the type and the action of mechanism of antifungal angent were described. The research and development of antirungal drugs were also explained in this thesis.Based on the study of structure-activity relationship (SAR) and mechanism of triazole derivatives, taking fluconazole as the leading compound, the target compounds were designed. 43 3-triazole-2-aryl-1-arylthiol-propan-2-ol derivatives were synthesized, they had not been reported in literatures. The synthesis rude were designed by starting from 1,3-difluorobenzene and chloroacetyl chloride, and following the Friedel-Crafts acylation, epoxidation, nucleophilic substitution and monoxidation or dioxidation. The structures of the new compounds were confirmed by ~1H-NMR and MS.The test of target compounds on antifungal activity is in process.