The Relationship And Clinical Significance Between Seasonal Climate And The Levels Of Plasma E, NE And CRH In Hypertensive Disorder Complicating Pregnancy

Objective:1. Through to detect the levels of plasma E and NE and CRH in normalpregnancies and HDCP patients, and analyzing its role in the occurrence anddevelopment of HDCP, in order to provide a theoretical basis for the pathogenesis ofHDCP.2. Comparing the relationship between the different seasons and the levels ofplasma E and NE and CRH in normal pregnancies and HDCP patients, analyzing theinfluence of different climate on E and NE and CRH, to provide new ideas for theprevention of HDCP and preventing the progression of the disease.Methods:1. Subject investigated:90cases of HDCP patients were chose randomly as thestudy group at January2009to January2010in Jiangxi Province maternity and childcare hospital, including45cases of gestational hypertension and45cases ofpreeclampsia. and we chose60cases of normal pregnancies as the control group atthe same period; According to the climate conditions, the year was divided into threeseason:they were winter group (from Nov. to Feb.),summer group (from Jun. to Aug.)and transitional season group (from Mar. to May and from Sep. to Oct.).And eachseasonal group had30cases of HDCP patients and20cases of normal pregnan-cies.The standard of the selected time in each seasonal group as the admission time.2. Research methods: The levels of plasma E and NE and CRH in90cases ofHDCP patients and60cases of normal pregnancies were detected by Elisa.Results:1. The comparison of the levels of plasma E and NE and CRH in HDCP patientsand normal pregnancies in each seasonal group:Both E and NE and CRH raised with the increasing of the severity of the diseasein each seasonal group, and compared to the control group and gestational hyperte-nsion at the same seasonal group, the levels of plasma E and NE in preeclampsia ineach seasonal group was considerably higher(P<0.001). Compared to the control group, the levels of plasma CRH in preeclampsia in each seasonal group wasconsiderably higher (P<0.05; P<0.001).2. The relationship between the plasma E and NE and CRH in HDCP patients:We used the linear correlation analysis, Plasma NE and E had a positivecorrelation in HDCP patients (P<0.001), NE and CRH also had a positive correlation(P<0.001).3. The relationship between birth weight and the levels of plasma CRH in HDCPpatients:The results suggested that the levels of plasma CRH in the control group andbirth weight had no obvious correlation (P>0.05), the levels of plasma CRH in HDCPpatients and birth weight had a negative correlation (P<0.05).4. The comparison of the levels of plasma E and NE and CRH in HDCP patientsand normal pregnancies in different seasonal group:The winter and summer season group compared to the transitional season group,the levels of plasma E and NE and CRH in the control group and the study group washigher, and the winter group compared to the transitional season group, the levels ofplasma E in the control group and the study group was considerably higher (P<0.05;P<0.001),and winter group compared to summer group,the levels of plasma E inpreeclampsia was higher(P<0.001);the winter group compared to the summer groupand the transitional season group, the levels of plasma NE in the study group wasconsiderably higher(P<0.001);The winter group compared to transitional seasongroup, the levels of plasma CRH in preeclampsia was higher(P<0.001);But in thecontrol group and the gestational hypertension, compared to the summer group andtransitional season group, the levels of plasma CRH in winter group was notobviously higher(P>0.05).Conclusions:1. The levels of plasma E and NE and CRH was increased in HDCP patients, andhad a positive correlation with the severity of the disease, maybe one of the etiologyof HDCP.2. Testing the levels of plasma E and NE and CRH, maybe a auxiliary role topredict the occurrence of HDCP. 3. Cold climate in winter may be one of an important inducement to HDCP.4. Under the stress of cold climate in winter, may through increasing the activityof SAM system and HPA axis, causes more of the secretion of E and NE and CRH,and then HDCP is happening.