CKD Patients With Average Heart Rate At Night, Angiotensin II And Atherosclerosis

Cardiovascular disease(CVD) is the most common and serious complication in chronic kidney disease(CKD),as well as the main cause of death in CKD. As one of the independent predictors of cardiovascular morbidity and mortality,heart rate,however,is still overlooked by clinicians of the importance of CVD.The purpose of this study is to explore the correlation between arterial stiffness and resting heart rate,24-hour average heart rate,average heart rate during the day,and night-time average heart rate in patients of CKD.Methods:According to the definition of CKD from K/DOQI guide made by American kidney foundation (NKF),140patients were choose. Measuring the following biochemical index:large and small arteryelasticity index. weight, height. blood pressure.resting heart rate.24-hour average heart rate, average heart rate during the day, night-time average heart rate,renal function,uric acid, blood sugar. blood fat,Cross product of calcium and phosphoniumet.Result:Patients with large arterial clastieity index and age (r-0.387,P<0.01), SBP(r-0.382,P<0.01),PP(r=-0.445,P<0.01),nighttime average heart rate(r-0.235,P<0.01)was negatively correlated. and BMI(r-0.222,P<0.01),HBG(r0.299,P<0.01),GFR(r-0.318,P<0.01).small arterial elasticity index (r-0.206,P <0.05) was positively correlated. All indicators into the regression equation. multiple regression analysis showed that large arterial elasticity index with BMI (P<0.01).PP(P<0.01).age (p<0.01).gender (P<0.01).nighttime average heart cate(P<0.01)were independently associated. Conclusion:Nighttime average heart rate and large arterial elasticity index were negatively correlated, which suggesting that CKD nighttime average heart rate fast was related to the level of arterial stiffness. Nighttime average heart rate, as one of the risk factors of CVD, is possible in patients of CKD. Objective:To investigate the correlation of serum angiotensin II concentration and arterial stiffness in chronic kidney disease patients.Methods:According to the definition of CKD from K/DOQI guide made by American kidney foundation (NKF),32patients were choose. Measuring the following biochemical index:large artery elasticity index, weight, height, blood pressure, renal function,uric acid, blood sugar, blood fat, Cross product of calcium and phosphoniumet. ELISA for measuring serum angiotensin II concentration (each sample measured with two holes).Results:The concentration of low-artery elasticity index group angiotensin II (0.99±0.90ng/ml). significantly higher than the high-artery elasticity index group of angiotensin Ⅱ (0.51±0.21ng/ml) concentration. Pearson correlation analysis showed a negative correlation (r=-0.418,P<0.05) and of Ang Ⅱ concentration and arterial elasticity indices.Conclusion:The statistical significance of the level of arterial elasticity index two groups of CKD in patients with serum angiotensin Ⅱ concentration and angiotensin Ⅱ concentration and arterial elasticity index was negatively correlated, suggesting that the higher the concentration of angiotensin Ⅱ. arterial elasticity is the worse.