Meta-Analysis Of The Relationship Between Migraine And Ischemic Stroke Risk

Objectives:Objectives:Through the Meta-analysis of systematic reviews of migraine and ischemic stroke, especially young women, as well as with aura typical migraine. Provide an objective reference evidence for the prevention of ischemic stroke.Methods:Using the Review Manager software5and Stata9.2do meta-analysis for the extracted datas which from the collected17case control studys, using odds ratio (odds ratio, OR) for effect indicators and test for heterogeneity, select the fixed effects model or randomeffects model combined OR and95%CI, performed a subgroup analysis of the data and the cumulative analysis, sensitivity analysis, and assessment of publication bias. Retrieval pubmed (1995-2011), ovid (1995-2011), Chinese Biomedical Literature Database of CBM (1995-2011). Qinghua Tong Fang journals database the CNKI (1995-2011), VIP (1995-2011) full text database. Blinded evaluation of the quality of the literature according to the literature of design methodology, the allocation scheme. Two authors independently extracted data, and take the quality of evaluations, there are differences to be resolved through consultation. Contact the author write when necessary, and manually search for related conference papers.Results:This article were included in17studies, including13in English,4in Chinese, a cumulative total of cases5505,1151positive;11384in the control group,1044positive, test for heterogeneity X2=90.21, P<0.00001, I2=82%, the choice of the random effects model analysis OR2.59,95%CI (2.01-3.35), does not contain1,having statistically significant, indicating that the risk of having the ischemic stroke increased2.59fold which suffering from migraine patients compared with not suffering from migraine. To a certain extent, migraine is a risk factor for ischemic stroke. Subgroup analysis of Chinese literature OR5.20(4.12-6.56), English literature OR2.11(1.68-2.65); only study of women with migraines OR2.55(1.77-3.65), does not distinguish gender migraine research OR2.61(1.78-3.84);<50years old research OR2.30(1.75-3.02), migraine headaches over the age of50documents group OR4.31(2.85-6.53), these results did not include1, were statistically significant, the description of migraine is a risk factor for ischemic stroke. Conducted a meta-analysis the ones who accompanied with migraine with aura as well as the relationship between young female patients with migraine and stroke respectively, with migraine with aura OR1.24(0.85-1.79), contains1,is non-significant; young women with migraines OR2.40(1.71-3.35), does not include1,indicating that young women with migraines in patients having ischemic stroke prevalence compared with the control group tended to increase, the ratio of2.40times, and statistically significant.The quality of the literature through quantitative evaluation, the evaluation suggests needing2331no significant literatures in order to change the test results so that the results not statistically significant, indicating that the results are reliable.Conclusions:This study suggests that migraine is a risk factor of ischemic stroke in young female migraine patients,the risk of ischemic stroke are at higher than other groups, but if the migraine with aura compared with common migraine patients increased the risk of suffering from ischemic stroke remains to be more high-quality research to analyze and explore.