The Diagnostic Value Of Heart Fatty-acid Binding Protein In Acute Ischemic Cerebrovascular Disease

Objective:By detecting the serum concentrations of heart fatty-acidbinding protein (H-FABP) in acute cerebral infarction (ACI) patients andtransient ischemic attack (TIA) patients, the value of H-FABP was exploredin early diagnosis and severity evaluation of ACI, and the diagnostic value ofH-FABP was evaluated in distinguishing patients suffered ACI and TIA.Methods:1The46patients with ACI,25patients with TIA, and17age-matchedhealthy volunteers from department of neurology of the second hospital ofhebei medical university were recruited in the present study during the periodfrom2010/10to2012/2. The H-FABP concentrations and other laboratoryparameters including blood glucose, lipids, renal functions, myocardialenzymes were detected, while electrocardiogram (ECG) and magneticresonance imaging (MRI) scanning were performed after admission. Thevolume, number and location of the infarctions were determined by MRIscanning. H-FABP concentrations were compared among different groups.2The severity of the neurological deficit in ACI group was quantified by theNational Institutes of Health Stroke Scale (NIHSS) score. Then therelationship between the NIHSS score and serum H-FABP concentrationswere analyzed in the ACI group.3TIA patients with lacunar infarction and without lacunar infarction weredetermined by MRI scanning, and the differences of H-FABP concentrationsbetween TIA patients with lacunar infarction and TIA patients without lacunarinfarction were analyzed.Results:1H-FABP concentrations showed significantly higher in the ACI group andTIA group than that in the control group (p<0.05), while no significant difference between ACI group and TIA group (p＞0.05). Compared with thecontrol group, H-FABP concentration in each subgroup of ACI group (severe,moderate and mild neurological deficit which was quantified by the NationalInstitutes of Health Stroke Scale score) and in each subgroup of TIA groupwith lacunar infarction and without lacunar infarction was significantlyincreased (p<0.05). In ACI group, H-FABP concentration in severeneurological deficit subgroup was higher than that of moderate and mildneurological deficit subgroup (p<0.05), but there was no significant differencebetween the moderate and mild neurological deficit subgroup (p＞0.05). InTIA patients, H-FABP concentrations showed no significant differencebetween subgroup with lacunar infarction and without lacunar infarction (p＞0.05).2H-FABP concentrations showed significantly higher both in the anteriorcirculation infarction subgroup and posterior circulation infarction subgroupof ACI group than that of the control group (p<0.05), While no significantdifference between the anterior circulation infarction subgroup and posteriorcirculation infarction subgroup (p＞0.05).3H-FABP concentrations showed significantly higher both in the singleinfarction subgroup and multiple infarction subgroup of ACI group than thatof the control group (p<0.05), While showed no significant difference betweenthe single infarction subgroup and multiple infarction subgroup (p＞0.05)4In the single infarction of ACI group, the concentrations of H-FABP withdifferent size of cerebral lesion were significantly higher than that of thecontrol group (p<0.05). In the ACI group, H-FABP concentration in thepatients with large cerebral infarction was higher than that in the patients withmedium or small cerebral infarction (p<0.05), but there was no significantdifference between medium and small infarction patients (p＞0.05).Conclusions:1The serum H-FABP concentrations of ACI patients increased in the earlystage, and were significantly positively associated with the severity of theneurological deficit and the infarction volume. The serum H-FABP might contribute to the early diagnosis of ACI.2The serum H-FABP was not a reliable parameter in the differentialdiagnosis of ACI and TIA patients...