| Background Bronchopulmonary Dysplasia(BPD)is also called neonatal chronic lung diseases(CLD),it is a common disease in the preterm infants,especially small premature respiratory system.It has a unique clinical,radiographic,and histologic features.Epidemiological data in recent years reveal that the incidence of BPD has a tendency to increase year by year.BPD becomes the leading causes of infantile chronic respiratory disease,and seriously affects the survival rate and quality of life in preterm neonates.With the gradually in-depth study of BPD,we found that its etiology and pathogenesis are complicated,and its related risk factors are many.BPD is caused by lots of factors comprehensively.We have to in-depth study of etiology and risk factors,so we can strengthen preventive measures and reduce the incidence of BPD and its severity from the perspective of the etiology and risk factors.This study was to analyze general information and risk factors of BPD patients in our hospital in order to have an understanding of the risk factors associated with BPD,and provide the foundation for the clinical prevention and treatment of BPD.Methods 1.The analysis of risk factors in premature infants With bronchopulmonary dysplasia A restrospective analysis of 67 cases of patients with BPD in Shanghai children’s Hospital during 2008.1-2014.12 was implemented.At the same time,randomly selected the same period of hospitalization,the same gestational age range,the same number of non BPD patients as control group,to analyze and compare the clinical characteristics of the two groups of data.2.Effects of inhaled corticosteroids on time,mortality and growth of BPD in children A retrospective analysis of 67 cases of patients with BPDseven in Shanghai children’s hospital during 2008.01-2014.12 was implemented.They were divided into inhaled glucocorticoid group and not inhale glucocorticoid group.Two groups of children with oxygen inhalation time,mortality and the growth indicators were compared to provide the basis for clinical hormone treatment.Results 1.The single factor analysis shows that the risk factors of BPD were gestational age of less than 28 weeks,birth weight less than 1250 g,male,maternal prenatal infection,premature rupture of membranes,mechanical ventilation time more than 7 days,sepsis,NRDS,and in the BPD group boy incidence rate is higher than that of girls,and the difference was statistically significant(P < 0.05).Risk factors,which were statistically significant in univariate analysis,were used as independent variables and BPD as dependent variables.Multivariate Logistic regression analysis showed that the independent risk factors for the occurrence of BPD were less than 28 weeks of gestational age,birth weight less than 1250 g,and mechanical ventilation more than 7 days.2.Compared with the not inhaled corticosteroid group,the average oxygen uptake time of the inhaled corticosteroid group was shorter,and the difference was statistically significant(P<0.05).There was no significant difference between the two groups in the mortality and the growth parameters(P>0.05).Conclusion 1.Preterm infants with a gestational age of less than 28 weeks,the boy,the birth weight less than 1250 g,maternal prenatal infection,premature rupture of membranes,mechanical ventilation time more than 7 days,sepsis,NRDS are the risk factors of BPD.Those risk factors should be avoided from a clinical point of view to reduce the incidence of BPD.Multivariate Logistic regression analysis showed that the independent risk factors for the occurrence of BPD were less than 28 weeks of gestational age,birth weight less than 1250 g,and mechanical ventilation more than 7 days.2.Atomizing inhaled corticosteroids can shorten the time of oxygen inhalation in children with BPD,without increasing mortality and inhibiting growth and development.Clinically atomizing inhaled corticosteroids can be treated with BPD. |
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