The Influence Of Acute Hypervolemic Hemodilution On Target-controlled Infusion Of Rocuronium

Objective This study was designed to invesgate the effect of the acute hypervolemic hemodilution on target-controlled infusion of Rocuronium. Methods Thirty-six patients undergoing elective surgery under general anesthesia were randomly divided into two groups of 18 patients each,which all in ASAⅡ—Ⅱwithout any neuromuscular disease. In groupⅠ, the patients were given normal liquid durig operation, In groupⅡ, AHHD was conducted with preoperative infusion of 15 ml/kg 6% hydroxyethyl starch at a rate of 50ml/kg. Neuromuscular fuction was awwessed using an accelograph with tran-of-four stimulation at wrist..All patients were premedicated with atropine O.Olmg/kg, diazepam 0.2mg/kg intramuscularly 30min before anesthesia and 10 min before induce sufentanyl 0.1ug·kg-1 was given intravously. After topical anesthesia with 2 mll% dicaine, anesthesia was induced with IV midazolam 0.01 mg/kg,sufentanyl 0.2-0.4ug/kg and propofol 2-3mg/kg. Without the aid of any muscle relaxants the trachea was intubated. After trache all patients were given rocuronium by target-controlled infusion(3ug/ml),then change concentration of'TCl to maintain the rate of TOF from 1 to 10. We then observe the concerntration, the recovery index and T125% recovery time. Results Onset times of rocuronium in two groups were 121s±23.5 and 102±22.Is (P<0.05); T125% recovery time,recovery index and the maintain concentration were 34.2±6.4,36.8±7.8(min);11.7±2.7,12.4±3.6(min)and0.81±0.12,0.79±0.09(ug/ml). Conclusions It is suggested that AHHD can accelerate the muscular relaxation onset time of rocuronium.but the different of potentiated effect between the two is not significant.