Concomitant Exotropia Rectus Of Igf-��, Expression Of Annexina1,

Objective To investigate the expression of IGF-1 and Annexin 1 of extra ocular muscles (EOMs) in patients with concomitant extropia. To explore the role of IGF-1 and Annexin lin the etiology of concomitant extropia.Methods Collect 16 cases accepted surgery with concomitant extropia and name strabismus group, then divided them into 2 groups which were the group of children with concomitant extropia and the group of adults with concomitant extropia. Medial rectus muscles were obtained with agreement from patients accepted surgical resection. Control muscles were obtained from patients with eyeballs removed with injury and corneal transplant donors. Cross sections were stained immunochemically and measured the mean optical density according to the expression of IGF-1 and Annexin 1 in EOMs. To compare the difference in different groups and analyze the relationship between the expression of IGF-1 and Annexin 1 and the age and the strabismus degree.Results①We discovered IGF-1 and Annexin 1 expression in EOMs of strabismus group and control group. There were significant differences (P< 0.01) in the expression of IGF-1 and Annexin A1between the group of children with concomitant extropia and the group of adults with concomitant extropia, the control group and the group of adults with concomitant extropia, the group of adults with concomitant extropia and the strabismus group. The formers had higher level than the latters.②There were significant differences (P< 0.01) in the expression of IGF-1 and Annexin A1 between the strabismus group and the control group. And the former was lower than the latter.③There were negative relationship between IGF-1 and Annexin A1expression and prism diopter of deviation and patients' age.Conclusion The decreased level of IGF-1 and Annexin 1 expression may participate in the incidence of concomitant extropia by inhibit the mechanism of self-renewal and repair; With age, the level of IGF-land Annexin A1 is down gradually, we consider it may be the cause of concomitant extropia with deteriorating process.