| Objective:To investigate the expression of Bmi-1 and hTERT protein in gastric carcinoma, to explore their clinic pathologic significance and their relationship.Methods:The expression of Bmi-1 and hTERT protein was detected immunohistochemically in 70 gastric carcinoma specimens and 20 chronic atrophic gastritis and 10 adjacent non-cancerous samples.Results:(1) The levels of Bmi-1 and hTERT protein in gastric cancer specimens were significantly higher than those in chronic atrophic gastritis and adjacent non-cancerous tissues (Z=-5.032～-3.793, P<0.01 Respectively)(2)The positive expression of Bmi-1 and hTERT protein was closely correlated with invasive depth, clinical stage and lymph node metastasis (Z=-5.198～30.971, P<0.01 Respectively),On the other hand, it was not correlated with gender, Borrmann classification and differentiation(Z=-1.825～1.940, P>0.05 Respectively).(3)The expression of Bmi-1 in gastric cancer was highly related with hTERT (r=0.940, P=0.000)。Conclusion:(1) Bmi-1 and hTERT are both associated with the occurrence and development of gastric cancer.(2) Positive correlation is found between Bmi-1 and hTERT protein in gastric cancer may suggest that over-expression of Bmi-1 and hTERT protein has synergetic effect in the process of occurrence and development of gastric cancer.(3) Combined detection of Bmi-1 and hTERT may be useful in early diagnosis, metastasis predicting, and prognosis evaluating of gastric cancer. It may also be possible for providing new targets for molecular treatment in gastric cancer. |
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