The Expression And Significance Of HMGB1 And MMP-9 In Human AAA

Objective To study the effects of high mobility group boxl protein (HMGB1) and matrix metalloproteinase-9(MMP-9) in the pathogenesis of unruptured abdominal aortic aneurysms(AAAs) and ruptured abdominal aortic aneurysms (RAAAs) by localizing the expression of HMGB1 and MMP-9 in the aneurysmal tissues.Methods The present study included 30 specimens unruptured AAAs (9 small AAA; <5.0cm,15 moderate-diameter AAA:5.0～7.0cm,6 large AAA:≥7.0cm),12 RAAAs and 10 normal abdominal aorta tissues; the expession of HMGB1 and MMP-9 were investigated by immunohistochemistry.Results The expression rates of HMGB1 and MMP-9 in AAAs and RAAAs were obviously higher than that of normal abdominal aorta tissues (P<0.05);The expression rate of MMP-9 in RAAAs was significantly higher than that AAAs(P=0.045):The positive rates of MMP-9 in RAAAs and large AAAs were sigificantly higher than those of small and moderate-diameter AAA(P=0.01);the expression of HMGB1 had no significant difference among small AAA,moderate diameter,large and ruptured AAA(P> 0.05);The expression rate of MMP-9 in patients with cardiocerebrovascular diseases was obviously higher than that in the negative group(P=0.027).HMGB1 had no correlation with MMP-9 in AAA(P=0.767),But the expression of HMGB1 was positive correlated with that of MMP-9 in RAAA(P=0.016).Conclusion MMP-9 may be responsible for expansion and rupture of AAA.HMGB 1 and MMP-9 play a positive cooperative effect in ruptured abdominal aortic aneurysm tissues.HMGB1 and MMP-9 are considered to play role in pathogenesis of AAA.