The Expression And Clinical Significance Of Serum High Mobility Group Box1 Protein In Patients With Systemic Lupus Erythematosus

Objective: To investigate the expression and clinical significance of serum high mobility group box1 protein(HMGB1)in patients with systemic lupus erythematosus(SLE).Method: The levels of serum HMGB1 were measured in 65 SLE Chinese patients and 25 healthy persons by the method of enzyme-linked immunosorbent assay (ELISA),65 SLE patients were divided into different groups according to the SLE disease activity index (SLEDAI) score and renal involvement :50 patients at active phase and 15 at stable stage; 38 patients with nephritis and 27 patients without nephritis. And the correlation between HMGB1 levels and SLE other disease activity parameters and renal injury was analyzed.Results:⑴The levels of serum HMGB1 in SLE patients were significantly higher than that in normal controls (P<0.05).⑵The levels of serum HMGB1 in SLE patients with active lupus were significantly higher than that of in those without active lupus(P<0.05).⑶The levels of serum HMGB1 in lupus nephritis patients were significantly higher than that of in those without lupus nephritis (P<0.05).⑷The levels of serum HMGB1 was significantly positively correlated with SLE disease activity index (SLEDAI) scores(P<0.05).⑸The levels of serum HMGB1 was positively correlated with anti ds-DNA antibody levels(P<0.05).⑹The levels of serum HMGB1 was significantly negatively correlated with C3 levels(P<0.05).⑺The levels of serum HMGB1 in lupus nephritis were positively correlated with these renal injury's clinical indexes (including urine ALB,urine IgG,urine IgA,urine IgM,urineα2-MG) and 24 hours urine protein(24hUpro)(P<0.05).Concluions: The levels of serum HMGB1 were significantly elevated in SLE patients compared with that of in healthy person, the levels of serum HMGB1 in active SLE were higher than that in those without active lupus, and higher in LN than those without LN. The levels of serum HMGB1 was significantly correlated with anti ds-DNA antibody levels, which reveals HMGB1 participate in the pathogenesis of SLE and LN, and the way of inflammation inducing effects maybe correlated with the synthesis of anti ds-DNA antibody. Besides, the levels of serum HMGB1 are positively correlated with SLEDAI scores. HMGB1 can display the state of disease activity and it is also suggested that HMGB1 can be one of the indicator of the disease activity and renal injury in patients with SLE.