Effect Of Pre-emptive Analgesia With Parecoxib On Cardiovascular Response And The Pain After Modified Radical Mastectomy

Objective To study the effect of pre-emptive analgesia with Parecoxib on cardiovascular response and the pain after modified radical mastectomy.Methods 50 breast cancer patients with ASA I orⅡundergoing modified radical mastectomy were selected and modified randomly divided into 2 groups:the Parecoxib group (Group P,n=25) and the control group (Group C,n=25)in randomized and double-blind fashion. Anesthesia was induced with propofol and fentanyl.Before induction of anesthesia 10 minutes,parecoxib sodium injection 40 mg was given IV in Group P, equivalent dose of 0.9% NaCl was injected as control in Group C. Mean artery pressure(MAP) and heart rate(HR) were detected at different time points which including times after 5 minutes entering the operation room (TO), immediately injection parecoxib sodium or 0.9% NaCl (T1), at the beginning of operation(T2), and the end of operation (T3).The usa ofvasoactive drugs during perioperative peried, time of awakening,extubation and consciousness were recorded.Visual analog scale(VAS)at 0.5,2,4and24 h after operation were also recorded.Results The concentration of MAP and HR at T2 and T3 were significantly lower than those in the Group C.The VAS pain scores in the Group P were significantly lower than those in the Group C.There are no significant differences in the time of awakening,extubation and consciousness.Conclusion Intravenous Parecoxib may produce pre-emptive effect in modified radical mastectomy,and can effectively prevent cardiovascular response.