Effect Of Pre-Emptive Analgesia With Lornoxicam On Pain And The Expression Of P-Selectin On Platelet After Modified Radical Mastectomy

OBEJECTIVE:Lornoxicam is a new analgesic which belongs to the oxicam group of nonsteroidal anti-inflammatory grugs (NSAIDs) .The aim of this study is to determine whether lornoxicam has a preemptive analgesic effect to the patients who undergo modified radical mastectomy .Because lornoxicam inhibits the synthesis of prostaglandins and thromboxane by inhibition of the enzyme cyclooxygenase(COX),we assume it perhaps affects platelet activation and aggregation,which may lead to uncontrollable peri- and postoperative hemorrhage.To study the effect of lonoxicam on platelet function ,we investigate the surface expression of p-selectin on platelet by a flow-cytometric assay.METHODS:After obtaining a written informed consent from patients,sixty ASA â… -â…¡ patients, aged 40-60yr,weighted 40-60Kg, who were scheduled for modified radical mastectomy were included in the study. All patients were randomly divided into two goups.Patients undergoed breast surgery under general anesthesia with mechanic ventalition,remifentanil and isoflurane maintained anesthesia. When operation was over and the patient could be called weaken ,intratracheal tube was extracted,all patients were sent to ward room safely. Group I was administered 16mg of lornoxicam iv.30 minutes prior to surgery ,Group â…¡ was administered 4ml placebo.2ml blood was drawn from a...