Epidemiologic Pictures Of Kawasaki Disease In The Children's Hospital Affiliated To Soochow University From 2006 Through 2010

Objective: To investigate the epidemiologic pictures of Kawasaki disease(KD)in Suzhou from 2006 through 2010, and to analyze the high risk factors of KD patients complicated with coronary artery lesions(CALs).Methods: Retrospective reviews of medical records from the Children's Hospital Affiliated to Soochow University were done to identify inpatients with KD from 2006 through 2010. The high risk factors for KD with complication of cardiovascular disease were investigated. The data were analized by SPSS 16.0 software with X~2 test. Measurement data were showed by (X|-)±s and were calculated by t test. A value of P <0.05 was considered statistically significant.Results: There were 445 inpatients diagnosed as KD in the Children's Hospital of Soochow University from 2006 through 2010. The male/female ratio was 1.91:1. Among the total patients, children aged 0-2 years, 2-5 years and larger than 5 years accounted for 61.12%, 28.09% and 10.79% respectively. Although KD occurs year-round, somewhat higher incidences were seen from March through to June and September. The percentage of patients who were diagnosed as complete KD was 74.83%. All patients had fever, 378(84.94%) cases had fissured lips.The incidence of KD complicated with cardiac involvement and CALs was 21.46% and 18.72% respectively. Approximately 2.82% patients had no response to immunoglobulin. A second onset of the disease occurred in 1.57% of patients. Nonresponse to immunoglobulin, anemia, hypoalbuminemia and elevated erythrocyte sedimentation rate were significantly related to the incidence of coronary artery lesion ( P<0.05).Conclusions: This research approximately reflects that:the male children have a higher incidence than female children in Suzhou,the peak age is below two years old,the disease occurred more frequently in spring. Fissured lips is the most common clinical symptom except for fever. The incidence of CALs is lower than that reported in Shanghai, but remarkably higher than those in Japan. Nonresponse to immunoglobulin, anemia, hypoalbuminemia and elevated erythrocyte sedimentation rate are significantly related to CALs.