| Objective: To explore the clinical features, diagnosis, treatment and prognosis of gastrointestinal stromal tumor (GIST) and elevate the level on diagnosis and treatment of GIST.Methods: A retrospective analysis was conducted in 46 patients with GIST who were treated by the second affiliated hospital of Dalian Medical University, from June 2002 to December 2008. The clinical data of all the patients with GIST were analyzed retrospectively.Results: 24 patients were male, and the others were female, with an average age 58, from 17 to 74. There were 28 and 11 GIST deriving from stomach and small intestine respectively .The main symptoms were abdominal pain (69.6%) and GI bleeding (21.7%). All the patients were treated by operation, with 11 local resections, 27 complete resections and 8 extended resections. The median size of tumor was 5.11cm in diameter. 42 of 46(91.3%) were positive for CD117, 37(80.4%) positive for CD34. The 2-year survival rate of mitotic count≤5/50HPE group and >5/50 HPE group were 89.7% and 70.6% (P<0.05) respectively. The 2–year survival rate for tumors < 5cm and≥5cm were 90.0% and 76.9% (P<0.05) respectively. The 2-year survival rate of patients with local resection, complete resection and extended resection were 90.9%,88.9% and 50.0% respectively .The 2-year survival rate of patients for inward-cavity, outward-cavity and mixed of tumor were 83.6%,88.7% and 66.9%(P>0.05) respectively .Conclusion: There was no difference between men and women in GIST incidence. Stomach and small intestine were the main primary sites. The primary treatment of GIST is surgery. Mitotic count and tumor size are found to be important indication of the prognosis, the type of surgery and growth pattern of tumor do not affect the prognosis. |
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