Symptoms Of Children With Epilepsy And Analysis Of MRI-related Changes

Objective:Epilepsy is the most common pediatric neurological diseases. Based on the study of 164 children admitted to our hospital, including characteristics symptoms of epilepsy about children, type of clinical seizures, Electroencephalography (EEG) and structural abnormalities found on MRI were classified as significant (yes/no) based on whether they were presumed to be related to the seizure condition.MRI in the diagnosis of epilepsy, location, nature and the application value of surgery.Method:One hundred and sixty-four of children diagnosed of epilepsy were selected in our hospital from March 2008 to January 2011 and been down the EEG and MRI test. Collection of basic information of cases and clinical data; gender, age, onset age, duration of symptoms, past history, the mother pregnancy history, family history, auxiliary examination of VEEG and brain MRI. The diagnostic criteria refer to the 1989 ILAE epilepsy and epilepsy syndrome, according to the specific cause of etiology, the patients were divided into idiopathic epilepsy, symptomatic epilepsy and cryptogenic epilepsy. Epileptic syndromes according to the seizure classification introduced in ILAE1981:focal seizures, generalized seizures and the various episodes of unknown.Results:Clinical characteristic of epilepsy:In this study, a total of 164 cases (84 male and 80 female). The age of patients ranged from 3 months to 14 years old (median age 4 year).The age at seizure onset ranged from one month to 14 years (median age 3.5years).The duration of the epilepsy was 0.5 to 10 years (median age 1.2years) a total of 164 cases were considered 16 idiopathic epilepsy(9.7%),126 symptomatic epilepsy(76.8%),22 cryptogenic epilepsy (13.4%).According to the medical history, Auxiliary examination tests and effects to AEDs,1Landau-Kleffner,5 patients were considered LGS,5 benign childhood epilepsy with centrotemporal spike. Focal seizures are the most main form, accounting for 70.9%, especially in symptomatic epilepsy (the ratio was up to72%).The number of patients with symptomatic epilepsy was significantly higher than the frequency of idiopathic epilepsy and cryptogenic epilepsy.MRI performance:The results showed that 90 people of the epilepsy patients have abnormal MRI,49.3% of which found lesions on MRI.12 people were considered as the different degrees of brain atrophy (13.3%),14 showed a simple brain malacia (15.6%),14 human arachnoid cyst (15.6%),16 were cortical dysplasia (17.8%),consider the inflammation 3 people.3 had the hippocampus sclerosis (3.3%),2 had the human brain tumors, glioma or glial proliferation (2.2%),2 had hypoplastic corpus callosum (2.2%), a human cavernous vascular malformation, developmental disorders of myelin 7 (7.7%),16 magnetic resonance abnormalities in two or more types (17.8%), mostly combined with other abnormal type of malacia. Analysis of 90 cases in 164 children with epilepsy MRI abnormalities, EEG abnormalities 158 cases, EEG and MRI point to the same 28 lesions (31.1%).The number of hippocampal sclerosis, brain tumors and abnormal MRI clear were 3 and 2,And the results showed that EEG and MRI was 100% consistency.MRI detected cerebral malacia and EEG abnormalities possessed 50% consistency, while the myelin sheath with developmental disabilities and brain cyst had the extremely low consistency with epileptogenic EEG detection. Softening of the brain MRI detected lesions, hippocampal sclerosis, brain tumors are the cause of the epileptic focus more cysts, more specific developmental disorders of myelin.The onset of epileptic symptoms and MRI correlation:partial seizures in patients have higher MRI positive rate than patients with generalized seizures, and the difference between 2 types had statistically significant (P=0.02).Bilateral asymmetric MRI abnormalities of patients with partial seizures was more common, the difference also had statistically significant (P=0.048). Before we all think generalized seizures more than focal seizures. But MRI widely apply to clinic, More and more the etiology of epilepsy has been cleared. In recent years, this is focal seizures more than generalized seizures reason for children with epilepsy. This study of focal seizures is account for 70.9%.Conclusion:1.Seizures in many forms, focal seizures were the most common performance.2.MRI by identifying subtle changes in cortical structure and organization of signal intensity changes, identify causes of symptomatic epilepsy more sensitive and specific imaging method.3.MRI provides an effective means for the epileptic focus of the location.4.Clinical doctors and radiologists work together to make MRI the etiology of epilepsy further clarify.