Clinical Study Of The Treatment Of Primary Liver Cancer With Combination Of Atuologous CIK And Dendritic Cells And Interventional Therapy

Primary liver cancer has a high incidence of a disease in our country.Traditional surgery and regular radiation and chemotherapy are limited tocuring the liver cancer, portion relapse of the tumor, regeneration and far- awaymetastasis. Besides, The surgery and long-term radiation and chemotherapy cando a lot of harm to the health condition of the patents with tumor. And theimmune system is restricted, too. We are confused by how to improve the lifequality of the patients effectively, lengthen the survival time, and how to curethe patients who can't endure the surgery or the radiation and chemotherapy.Those who is not sensitive to radiation and chemotherapy, or in the later periodof the portion cancer and far- away metastasis, are in desperate need of solutionfor the clinical treatment.Nowadays, with the fast development of the minimally invasive surgeryand intervention, the chemotherapy embolism of liver arterial and Cryosurgeryof the tumor are major treatments of Primary liver cancer , which have theunique excellence and superior irreplaceableness. Cryosurgery can preciselyshow the pathological changes of targets, and put the probe on the targets underthe direction of the images. It can also monitor the garnering and releasing ofenergy in the process of Cryosurgery.With the basic research of the immunity study of tumor, the treatment of tumor is not only about the portion treatments, The immunoenhancementaltreatment is one of the most promising measures for liver cancer. It can restrainand kill the cancer cell through adjusting and strengthening the immunizationand the ability of fighting cancers, and one of them is called dendriticcells,which is Antigen presenting Cells. it can absorb, process and present Antigen,start the resistance immunity of the T cell. This has become one of the focus inthe area of the immunoenhancemental treatment of tumors.Another cell is called cytokine-induced killer cells , a group of heterogycells which are groomed for a period of time from cells of peripheral bloodcells. It has both the active anti-cancer features of T-lymphocytes, andwithout the limit of the NK-cells killing cancers. The researct shows that thecombination of dendriticcells and CIK-cells can kill the tumor cells moredirectly and effectively. But we can't find the exact report of the intervention ofDC-CIK cell treatment combining with minimally invasive surgery to primaryliver cancer. Therefore, this research is involved with it in order to improve thetreatment of Primary liver cancer. We researched into the treatment immunityof the 24 patients who are in the middle and later Primary liver cancer. Theresults shows that the intervention of DC-CIK cell treatment combining withminimally invasive surgery can improve the life quality of the patientseffectively, lengthen the survival time. It can also restrict the tumor and preventthe relapse and metastasis. In the meantime, It can Ease the immunosuppressionof chemotherapy, increase the tolerance of chemotherapy of the patients as well as improve the immunity. The research shows the interventionof DC-CIK cell treatment combining with minimally invasive surgery increasethe possibility of curing the primary liver cancer, lengthening the survival timeand improving the life quality of the patients. It is superior to the mere use ofminimally invasive surgery.