| Objective:To compare the efficacy of thoracic infusion of KLT and drinking Ten Jujube Decoction with only infusion of cisplatin in malignant pleural effusion of lung cancer after the closed thoracic drainageMaterials and Methods:1. Study:40 patients were advanced lung cancer and malignant pleural effusion confirmed cases from oncology inpatient Department of Chinese medicine hospital in Hubei Province during January 2010 to April 20112. Diagnostic criteria:①After X films, B-or chest CT and other imaging data and histological or cytological diagnosis of lung cancer information;②malignant pleural effusion by cytology;③in accordance with the general higher education, "fifth" National Planning textbook "Chinese medical science" in the TCM diagnostic criteria can be diagnosed as "hanging drink."3. Group:The confirmed cases were randomly divided into two groups, thoracic infusion of KLT and oral Ten Jujube Decoction called treatment group, a total of 20 cases,11 cases were male and 9 females, age 61.1±5.7 years. Pleural perfusion with DDP as a control group of 20 patients,10 patients were male and 10 females, aged 62.1±6.2 years.4. Pathologic conditions:treatment group,9 cases of adenocarcinoma, squamous cell carcinoma in 8 cases,3 cases of undifferentiated carcinoma; control group,10 cases of adenocarcinoma, squamous cell carcinoma,8 cases of undifferentiated carcinoma in 2 cases.5. Dialectical type:the treatment group has 12 cases yin ting xiong xie card,1 case xie fan xiong fei card,3 cases ying xu nei re card,4 cases luo qi bu he card; control group,13 cases of yin ting xiong xie card,1 case xie fan xiong fei card,2 cases ying xu nei re card,4 cases luo qi bu he card.6. Methods:All patients could tolerate wearing chest drainage, in the month prior to receiving the treatment did not further local or systemic chemotherapy, and no other drugs injected to the chest. All patients in the B-orientation, the routine chest built into the central venous catheter, an external drainage bag after a one-time continuous drainage, drainage volume in first day to 1000ml, the second days may be increased to daily from 1500 to 2000ml. To be sealed with heparin cap when not drainage, toltal 3 days, the pleural fluid should be drained as much as possible, the control group by the PICC catheter infusion of cisplatin 60mg powder with 40ml saline, dexamethasone 5mg, saline 10ml (washing tube),tell patients change position, supine, prone, left and right side of the 15min, and give symptomatic and supportive treatment. Treatment group by the PICC catheter infusion KLT injection (KLT from Zhejiang Pharmaceutical Co., Ltd. to develop and produce) 100m, dexamethasone 5mg, saline 10ml (red tube), tell patients change position, supine, prone, left and right side of the 15minl, and give symptomatic and supportive treatment, at the same time oral ten Ten Jujube Decoction. The control group, DDP intrapleural injection once a week for 4 weeks; treatment group use KLT intrapleural injection, a total of 4 weeks, daily oral Ten Jujube Decoction, a total of two 2 weeks.Results:After treatment efficacy of the treatment group compared (CR +PR) was 85% in the control group was (CR+PR) was 70%, statistically significant difference (p<0.05). Treatment group and control group before treatment Karnofsky score by the standard statistical analysis no significant difference (P> 0.05), treatment group and control group before and after their Karnofsky standard score was significantly different (P<0.05), that the two groups treatment has efficacy; two groups after treatment Karnofsky score also significantly different (P <0.05), therefore, the treatment group in improving the life quality of patients (Karnofsky score) was better than the control group. Treatment group during treatment and after treatment, only 2 cases of gastrointestinal reaction I°, no significant hematologic toxicity, but the control group have different levels of gastrointestinal reactions, mainly nausea, vomiting embolism, and 6 patients with varying degrees of bone marrow suppression, the X2 test, the treatment group and control group rate of gastrointestinal adverse reactions and the incidence of blood toxicity differences were statistically significant.Conclusion:Integrative Medicine of KLT perfusion and oral Ten Jujube Decoction have better efficacy in improving the quality of life of patients and reduced toxicity has obvious advantages than only perfusion with cisplatin for malignant pleural effusion of lung cancer, worthy of use in clinical practice. |
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