| Background:Psoriasis is a chronic inflammatory skin disease caused by genetic and environmental factors. It is easy to relapse and usually has a long course which effects seriously on physical and mental health of patients. Its prevalence varies in different places of the world. Race, geographic location and environment may be associated with the incidence of psoriasis. There are four types of psoriasis i.e. psoriasis vulgaris, erythrodermic psoriasis, pustular psoriasis and psoriatic arthritis according to the clinical features. Psoriasis vulgaris is the most common type. Two forms of psoriasis could be distinguished according to the age of onset, one with an early age onset and one with a late age onset. Patients with early age onset develop psoriasis before 40 years old while patients with late age onset develop the disorder after 40 years old.The prevalence of psoriasis in China in 1984 was 0.123%。It had grown to 0.47% according to a community-based survey conducted in six cities from six provinces in 2010. The epidemiological characteristics of psoriasis may be different in different areas and populations. The epidemiological data of psoriasis were not found in the local area. To provide reference for the large-scale epidemiological studies, it is essential to research the epidemiological characteristics of psoriasis in the local area.Objective:To investigate and summarize the epidemiological characteristics of patients with psoriasis vulgaris in the clinic of a hospital for skin diseases and provide countermeasures for the epidemiological study, prevention and therapy of psoriasis.Materials and Methods:An epidemiology investigation on 4523 patients with psoriasis vulgaris in a Hospital Information System (HIS) data base of a hospital for skin diseases was performed. The gender, ages, first onset age, course of disease, affected parts, lesion shape, stage, Psoriasis Area and Severity Index (PASI), season, inducing factors, early or late age onset, family history, as well as joint symptoms of patients with psoriasis were explored. SPSS 17.0 were used for statistical analysis.Results:1.The ratio of male to female in the group was 1.43:1 (2662:1861)2. The first onset ages varied from 8 days to 85 years old and the average was 26.99±13.74; The average of the first onset ages of male was 27.53±12.69, in female it was 26.23±15.10. The average of the first onset ages of male was older than that of female (P<0.05). The peak of the first onset ages in male was 20-30 years old while it was 10-20 years old in female.3.83.53%(3778/4523) patients had early age onset while 16.47%(745/4523) had late age onset.4. The course of all the patients with psoriasis varied from 3 days to 60 years (7.43±8.65). The average course of male was 7.37±8.56 years while it was 7.51±8.78 year in female. There was no difference in the two groups (P> 0.05)5. The most common affected parts were lower limbs 89.74%(4059/4523). The second were up limbs 86.09%(3894/4523).The third was trunk 83.44%(3774/4523). The least was mucosa 1.06%(48/4523)6. The most common lesion shape was plaque type 47.29%(2139/4523), the second was guttata type 23.13%(1046/4523) and the third was coin type 22.48%(1017/4523); The least was mucosa type 0.22%(10/4523) 7.57.42%(2597/4523) patients were in the stable stage.21.98%(994/4523) patients were in the advanced stage while 21.93%(992/4523) were in the dissipating stage.8. The average PASI of all patients was 6.33±5.62. The average PASI of early-onset patients was 6.13±5.21 while it was 7.33±7.21 in late-onset patients.; Statistic analysis showed that there was an significant differences between them (P<0.05).9.24.23%(1093/4523) patients had a family history.26.18%(989/3778) early-onset patients and 13.83%(103/745) late-onset patients had a family history. Statistic analysis showed that there was an significant differences between the two groups (P< 0.05).10. The most common inducing factor was biological factor (43.99%,494/1123). Most patients suffered from the disease in winter (47.88%,169/353) or spring (47.31%, 167/353); The third season was autumn 21.25%(75/353), The least season was summer 12.18%(43/353)11.14.87%(673/4523) patients had joint symptoms and 5.81% patients (112/1928) were confirmed with psoriasis arthritis.Conclusions:Male patients were more than female in the group. The average first onset age of male was older than that of female. The number of early-onset patients was more than that of the late-onset patients. Most patients had a long course. The most common affected parts were limbs. Chronic plaques psoriasis, guttate psoriasis and coin shape psoriasis were most common. Most patients were in the stable stage and were mild and moderate (PASI<10). The rate of the family history in the early-onset patients was more than that of late-onset patients. Biological factor and season are the most common inducing factors in the group. Patients with joint symptoms may have a probability combined with psoriasis arthritis. |
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