The Blood Glucose Control And Influencing Factors In Type 2 Diabetic Patients With Oral Hypoglycemic Agents

Objective: To investigate the condition of blood glucose control in type 2 diabetic mellitus with oral hypoglycemic agents, and analyze the influencing factors to provide reference for clinical treatment.Methods:This survey recruited outpatients suffered from T2DM during June 2010 to January 2011 in the Second Affiliated Hospital of Dalian Medical University. All patients received oral hypoglycemic agents at least three months. The general information about these patients was recorded and height, body weight, BMI, cholesterol, triglyeride, high density lipoprotein, low density lipoprotein, fasting plasma glucoses, glycosylated hemoglobin were detected. Regarding HbA1c≤6.5% or HbA1c<7% as the standard of blood glucose control respectively, comparing the influence of therapy regimens, age, diabetic duration, degree of education, diabetic macrovascular complications on blood glucose control. The influencing factors were further analyzed by Logistic regression.Results:1.300 outpatients suffered from T2DM with oral hypoglycemic agents therapy were recruited. Regarding HbA1c≤6.5% or HbA1c <7% as the standard of blood glucose control, the total eligible rates were 22% and 41% respectively.2. The patients applying three kinds of oral hypoglycemic agents had significantly low eligible rate and long diabetic duration comparing with those patients appliying one kind of oral hypoglycemic agents (7% vs 27%, P<0.05; 22% vs 51%, P<0.05;8.07±4.38y vs 5.64±3.78y, P<0.05).3.The eligible rate in patiens whose age≥70 years old was significantly lower than that in patients whose age <70 years old (14.6% vs 25.5%, p<0.05; 32.3% vs 45.1%, P<0.05). Meanwhile the diabetic duration was longer and the prevalence of diabetic macrovascular complications was higher in the former group than that in the latter group, the corresponding values were 7.26±4.38y vs 5.45±3.99y; 39.6% vs 17.6%, (P<0.05).4. The eligible rate in the group with diabetic duration >10 years was significantly lower than that in the group with diabetic duration <5 years (9.3% vs 27.6%, P<0.05; 18.6% vs 50.4%, P<0.05), and the prevalence of diabetic macrovascular complication was higher in the former group than that in the latter group (39.5% vs 17.9%, P<0.05).5. The eligible rate in the patients with higher education were significantly lower than that in the patients without higher education (18.8% vs 33.3%, P<0.05; 38.0% vs 51.5%, P<0.05).6. Logistic regression: age, beginning time of drug combination, diet, exercise, and diabetic education were the influencing factors to blood glucose control.Conclusions:1. The eligible rate of T2DM patients with oral hypoglycemic agent therapy in Dalian was low.2. The influencing factors to blood glucose control included age, beginning time of drug combination, diet, exercise and diabetic education.3. Not considering the age and macrovascular complications, using the uniform standard of HbA1c for all patients might be an important reason for low eligible rate.