Clinical Efficacy Of Deanxit Combined With Esomeprazole And Itopride In Treatment Of Refractory Gastroesophageal Reflux Disease In Elderly Patients

Objective: To evaluate the effect of deanxit combined with esomeprazole and itopride in treatment of refractory gastroesophageal reflux disease(RGERD) in elderly patients.Methods: According to the inclusion criteria we chosen 100 cases of refractory gastroesophageal reflux disease (RGERD) patients of outpatient and inpatient wards in the second affiliated hospital of Dalian medical university from may 2006 to march 2011, All patients were informed consent, 54 patients were male, female 46, aged 60-83 years, mean 66 years. The patients were randomly divided into two groups, the treatment group were 50 cases, including 28 males and 22 females; aged 60-80 years.the control group were 50 cases, including 26 males and 24 females; aged 61-83 years. Two groups by age and gender composition of statistical analysis showed no significant difference (p>0.05). The treatment group was treated with deanxit plus esomeprazole plus itopride, and the control group was treated with esomeprazole plus itopride. After 4 weeks, we estimated the clinical symptoms, quality of life, psychological status respectively.Results: After 4 weeks of treatment, the clinical symptoms in the treatment group were improved after treatment, 18 patients (36%)were cured, 25 cases (50%) were creumreidtt,e d2,2 cthasee sto (ta4l4 %eff)e wcteivree rreamtei twteads, 8th6e% t.o Itanl tehfef eccotinvtero rl agter owupa s1 616 c%as. eCs o(m22p%ar)e dw ethree effects after the treatment ,the clinical symptoms of the treatment group is better than the control group (p<0.05). SF-36 Health Survey Questionaire showed that quality of life of the treatment group and control group after treatment were improved on varying degrees, in the control group, bodily pain and mental health dimensions of integration significantly increased (p<0.05). After treatment, the improvement of quality of life was more obvious, including role physical, general health, bodily pain, role emotional, mental health dimensions (p<0.05).Zung self-rating depression and anxiety scale showed that psychological status of the treatment group and control group after treatment in patients whose depression and anxiety scores were decreased . but the treatment group compared to control group, improvement of depression and anxiety were more significant difference (p<0.05)Conclusions: Deanxit combined with esomeprazole and itopride in treatment of refractory gastroesophageal reflux disease in elderly patients has a high clinical efficacy. Psychological factors may play a role in treatment of refractory gastroesophageal reflux disease in elderly patients.