| Objective:The aim of the research is to investigate whether that the intervention measures of oral calcium,VitD,active VitD and exercise can induce the variations of concentration of blood calcium,blood phosphorus,blood alkaline phosphatase and relieve back pain and extremities pain.Methods:The investigation Mongolian group is picked out by questionnaire of dangerous factors of Osteoporosis Pine Bone Fracture which includes age 60 and above,low body weight,BMI < 19,non-violent fracture,genetic osteoporosis,the metabolic osteopathy that adults secreted little sex hormone,chronic glucocorticoid,loop diuretic,antiepileptic drug,thyrine or anticoagulant ingestion at one time.The object of survey should be postmenopausal women and accord with that two items of questionnaire ,take calcium≤600mg,VitD≤600IU per day,not take diphoshonate or fluorinating agent one year,not take calcitonin,female hormone,three months, not suffer from serious chronic liver and kidney disease,rheumatology disease,the system of enterohepatic disease,serious angiocardiopathy,movement inconvenience,alzheimers pisease,type I diabetes,metabolic osteopathy,malignant tumor,hyperthyrosis,kidney stones. We picked out four hundred individuals with osteoporosis and divided randomly into four groups,control group(group A):maintain original life; exercise group(group B):systematically and regularly do bone healthy movement;oral calcim and VitD group(group C):take calcium 600mg and VitD800IU per day;oral calcium and active VitD group(group D):take calcium 400mg and active VitD 0.23μg per day.We measured the concentration of blood calcium,blood phosphorus and blood alkaline phosphatase by the system of bone density measurement and gave a mark from0 to 10 for backaches and extremities pain with VAS. At last ,we adopted spss soft to compare non-intervention measured value with intervention value in intragroup and intergroup. Results: When we did not take any intervention measure ,the blood calcium mean concentration of four groups are respectively 2.17±0.17(mol/L),2.21±0.12(mol/L),2.08±0.19(mol/L),2.08±0.16(mol/L) ; blood phosphorus are 1.23±0.23(mol/L),1.19±0.21(mol/L),1.18±0.24(mol/L),2.04±9.76(mol/L); blood alkaline phosphatase are 95.64±45.49(u/L),170.80±65.33(u/L),192.15±62.84(u/L),201.26±58.30(u/L),bone density T: -1.90±0.35, -1.93±0.41, -1.93±0.41, -1.87±0.36 bone density. Z: 2.01±0.35, -2. 10±0.6,-2.20±0.37,-2.30±0.46,and marks of backache and extremities are 5.62±1.24,5.63±1.08,5.69±1.09,5.73±1.19,After intervention ,we measured values are that blood calcium concentration are respectively 2.12±0.16,2.27±0.10,2.15±0.13,2.42±0.11,blood phosphorus are 1.22±0.22,1.16±0.11,1.32±0.08,1.41±0.11, blood alkaline phosphatase are 95.64±45.59,187.80±67.32,193.15±62.64,204.26±58.30,and marks of backache and extremities are 5.76±1.13,1.92±1.16, 1.82±1.16, 1.21±0.95.bone density T: -1.91±0.37,-1.05±0.35-1.34±0.37,-0.72±0.37.bone density Z:-1.90±0.12, -1.86±0.15,-1.67±0.36-1.50±0.28. So we calculated out that three kinds of intervention approach can markedly increase the concentration of blood calcium and alkaline phosphatase, among which the oral calcium and active Vit D group is the best,and only the intervention of group C can raise the concentration of the blood phosphorus; Moreover,these intervention approach also can relieve backache ,but oral calcium and active Vit D can more effectively relieve backache, exercise can more effectively relieve extremities pain.Conclusion: oral calcium and Vit D should combine with movement that can more effectively treat osteoporosis. |
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