Research On The Effects Of Magnesium Sulfate In Intervening Early Patients With Acute Cholangitis

Objective: It is reported that acute cholangitis can be caused or accompanied by Oddi sphincter spasm, while what's important is Oddi sphincter spasm may correspondingly aggravate acute cholangitis further. Oddi sphincter spasm belongs to Sphincter of Oddi dyskinesia category which is a clinical common disease and being understood gradually in nowadays society. Studies have shown that magnesium sulfate can alleviate symptoms of the sphincter of Oddi spasm. Therefore, on the base of researching the patients with acute cholangitis, let's observe how magnesium sulfate can effect on cholangitis in the early stage.Method: By adopting retrospective study, 143 cases of early application of magnesium sulfate were chosen as the observation team while 141 patients who were untreated with magnesium sulfate as a control group. The patients with biliary-enteric anastomosis and malignancy are eliminated. Both of the teams are treated as standard non-surgical. 33% magnesium sulfate 50~60 ml (tube injection) of treatment is given to the observation team when hospitalizing, the same dose is given in every 8 hours. After 24~48 hours, observation will be performed on the rate of pain relief, temperature dropping, leukocyte reducing, emergency surgery happening (PTCD and traditional) as well as the status of defecation. Much more attention should be paid to the effects on the severe patients with magnesium sulfate treatment, comparing the population of pain relief as well as the emergency surgery statistics with the control team who is conducting the same activities at the same time. In addition, the pain relief rate for the patients who are hospitalized in different timing needs to be considered as well, which includes the time slots between 0 ~12 hours,12 ~ 24 hours and after 24 hours.Result: In observation group after 24-48 hours, the rate of pain relief, temperature dropping, leukocyte reducing and the status of defecation is significantly higher than the control team;while the happening rate of emergency surgery ( PTCD and traditional ) is lower than the control team. The result above is being of significance in statistical area (P<0.01). However, there is slightly difference for the severe cholangitis patients pertaining to the rate of emergency surgery happening and pain relief after 24~48 hours (P>0.05). The shorter the magnesium sulfate is injected, the faster the pain relief will be effected.Conclusion: Choosing magnesium sulfates to intervene early on acute cholangitis can alleviate the symptoms, reduce the happening rate of emergency surgery and also promote the bowel movements. Hence, we believe magnesium sulfate may alleviate the Oddi sphincter spasm, remove obstruction of the lower bile duct and control the development of acute cholangitis. But it seems not significant impact to acute cholangitis. The shorter the magnesium sulfate is injected, the faster the pain relief will be effected.