In Traditional Chinese Medicine To Reduce ��, �� Of Colorectal Cancer Recurrence And Metastasis After The Outcome Of The Clinical Series Of Studies To Explore

Bankground:In recent years, the number of people who get colorectal cancer has increased gradually. Colorectal cancer has become a major concern to Chinese among other malignant cancer types. According to Western statistic results, about 50%～60% of patients who are diagnosed of intestine cancer are already in the partial final stage (StageⅡ,Ⅲ). So far, colorectal cancer treatment mainly concentrates on surgery. And the partial recrudescence and the distant place replase are affect the colorectal cancer permanent control rate and the survival rate key.Therefore, the preventive care after surgery becomes very important. Repetitive colorectal cancer often happens 1-3 years after the surgery. The patient is identified as cured if repetitive cancer does not occur in 5 years. Within the 5 years after surgery, medical profession closely monitors the patient by paying regular visits and communicates effectively about patients conditions. People also believes that regular follow-up visits can improve patient satisfaction of the medical service overall. This article consists of three major groups:Colorectal cancer supplemental treatment with TCM comprehensive treament with a prospective cohort study (topic 1), Multicentre Cohort Study (topic 2), "Quxie capsule to reduces Stage II and III Colorectal Cancer after surgery"with double blind randomized controlled clinical trial (topic 3). By recording the results of random check-in phone calls and regular visits, we can follow up on the three groups and perform analysis, try to come up with reliable treatment plans for StageⅡandⅢcolorectal cancer.In China, expect for the internationally standardized chemotherapy, immune system treatment, and targeting therapy, TCM comprehensive treament has become another important component in assisting curing colorectal cancer after surgery treatment. Based on ample amount of research, it has been proven that combined with western treatment, TCM comprehensive treament can help reduce the chance of StageⅡ,ⅢColorectal cancer occurrance; therefore, plays an important role in the healing process.This article applies cohort study by observing 222 cases of stageⅡ,ⅢColorectral cancer patients who have been treated with TCM comprehensive treament (with the TCM medicine soup+one kind of Chinese Patent Medicines for more than one year) in addition to the traditional Western treatments.All patients were monitored for cancer migration.Objective:Probe into the clinical value of Using the Comprehensive Treament on the base of western conventional treament may reduce relapse and metastasis rate of stage II, III Colorectral cancer after surgery; summarize and discusses how to control and Improves the quality of Revisit.Methods:The topic 1 applies the a prospective cohort research technique. Two Third-level First-class Hospital collected 222 examples of stageⅡ,ⅢColorectral cancer patients after their surgery, most of their surgery is done from February,2000 to March,2006 or October,2001 to September,2008.115 examples from Beijing First-class Hospital patients treated with Western conventional treatment belong to the control group; 107 examples form Xiyuan hospital treated with Western conventional treament and TCM comprehensive treatment belong to the exposed group. The topic 2 applies the multi-central Cohort research technique. Norway and 8 domestic hospitals collects stageⅡ,ⅢColorectral cancer patients after surgery, with surgery time from April 1, 2007 to March,2009. The control group patients only accepts the Western conventional treament. The exposed group join the TCM comprehensive treatment. This report collects 78 examples from Xiyuan hospital. The topic 3 with double blind randomized controlled clinical trial (RCT), select 84 examplesⅡ,ⅢColorectral cancer after surgery, with surgery time taken place from August,2005 to May,2009. The experimental group applies Quxie capsule treatment. The control group was given the placebo capsule, and being revisited regularly with a follow-up visit 5 years later and then demolishly blind them. Three group of topic research need to make follow-up visits for 5 years. From July,2010, I undertook three topic research revisit work, adopted by the telephone to revisit primarily, every 3-6 months per visit, according to the 1,2,3,4,5 year relapse and metastasis rate of observation experimental group and the control topic, and the recrudescence transfer time.At the same time, I analyzed the record of the follow-up visits, and performed statistical analysis for further discussion.Results: From July,2010 to the end of April,2011 revisit results, topic 1 already loses visit rate by 14.78%. Since April,2010, revisit rate drops to 12.61%. By the fifty year, revisit rate is reduces to 5.86%, which is far below the research request of 10%. The 5 year revisit result of topic 1 has obtained in March,2011---- The 1,2,3,4,5 year relapse and metastasis rates of control group respectively are 6.09%(7/115),26.79%(30/112), 33.93%(38/112),41.28%(45/109) and 43.93%(47/107);The year recrudescence transfer rate of exposed topic 1,2,3,4,5 respectively is 0 (0/107),1.89%(2/106), 11.32%(12/106),12.62%(13/103) and 12.75%(13/102). The exposed group and the control group compare 1,2,3,4,5 year relapse and metastasis rate difference to have the significance (χ2=6.3328, P=0.0119;χ2=20.4118,0.000006;χ2=10.0069, P=0.0016;χ2=13.1325, P=0.0003; x2=14.0268, P=0.0002). In the exposed group, the position recrudescence relapse's time is 28 months; The control group is 21.5 months. Its 1,2, 3,4,5 years lose visit rate respectively are 0 (0/222),1.80%(4/222),1.80%(4/222), 4.50%(10/222),5.86%(13/222), all cases make a follow-up visit until now always lose visit rate are 12.61%(28/222), loses visit rate and the revisit time assumes is being obviously related, and so on is not obviously related with the patient age; Up to March,2011 last revisit:From 78 example experimental group case of topic 2, relapse and metastasis rate of 1,2,3 year respectively is 3.85%(3/78),13.51%(10/74), 13.51%(10/74). Its 1,2,3 years lose visit rate respectively are 0 (0/78),5.13%(4/78), 5.13%(4/78), all cases make a follow-up visit until now always lose visit rate are 5.13%(4/78), loses visit rate and the revisit time, the patient age and so on has not for the present presents obviously related;The topic 3 not yet now demolish blind, has 4 example rejections,1 example to withdraw automatically, its 1,2,3 year relapse and metastasis rate respectively is 6.33%(5/79),8.97%(7/78),14.47 (11/76). Its 1,2 years lose the visit rate distinction 0 (0/79),1.27%(1/79),3.80%(3/79), all cases make a follow-up visit until now always lose visit rate are 7.59%(6/79), loses visit rate and the revisit time, the patient age and so on has not for the present presents obviously related.Conclusion:Using the Comprehensive Treament on the base of western conventional treament may reduce relapse and metastasis rate of stageⅡ,ⅢColorectral cancer after the surgery can raise the clinical cure rate which has great clinical value. However, during the post surgery treatment, follow-up visits rate drops significantly as time passes. It appears that losed number of visits does not change with the follow-up visit the time the length to increase progressively or decreasing progressively, and will enter the group patient's age not to interfere with the revisit work advance, therefore needs in aspects and so on research subject preparation, revisit method way, outpatient service coordination, work connection to carry on the improvement optimization.