| The use of antibiotics to treat infectious diseases, scientists can be said for human health made a significant contribution to the cause. Once the correct and effective use of antibiotics, many diseases can be cured. However, in recent years the phenomenon of bacterial resistance has become an unavoidable reality. Antibiotic resistance can cause serious problems, such as health care cost increases, the incidence of infectious disease and mortality rise, and so on. This is a global concern important public health problem. According to Centers for Disease Control that the proper use of outpatient antibiotic prescriptions can prevent, or minimize use of unnecessary and excessive prescription of antibiotics. Clinical infection control is an effective solution to avoid bacterial resistance means.ObjectiveOf hospitalized patients infected with the pathogen distribution and resistance to antimicrobial agents for clinical anti-infective treatment of reference.MethodsFrom January 2009 to December 2010 in our hospital admitted 10,558 cases of respiratory patients to access the electronic scanning of cases, the statistics of cases of general bacterial, fungal culture and sensitivity test results identified, the use of Excel tables, databases, computing The composition of a variety of pathogens and the different types of bacteria than the antibiotic resistance rate (not cumulative repetition of the same patient strains).Results1 There are 4407 cases to mention a sputum culture check testing, inspection rate was 41.7%, sputum specimens were cultured for inspection, isolated bacteria 1294, the detection rate of 29.4%. Among them, the common bacteria 554, the top 10 were 180 Pseudomonas aeruginosa, Klebsiella pneumoniae 121, S. pneumoniae 37, Stenotrophomonas Aeromonas in food 35, Escherichia coli 26 , Acinetobacter baumannii, 25, 18 acid-producing Klebsiella, Enterobacter cloacae 14, 11 Staphylococcus aureus and Haemophilus influenzae 8, to 79 other bacteria, including Gram-negative bacilli 52, 27 Gram-positive cocci. Fungi, 740, 592 Candida albicans, Candida 73 smooth, 40 Candida tropicalis, Candida krusei 19, 7 Mucor, Aspergillus fumigatus 4, Penicillium 3 and mold 2.2 Most of the bacteria to penicillin, second and third generation cephalosporins, macrolides, sulfa antimicrobial drug resistance, aminoglycoside antibiotics and tetracycline resistance rates are higher for quinolone-resistant drug rate is relatively low, while the fourth generation cephalosporins,β-lactamase inhibitor compound preparation, carbapenems and glycopeptide antimicrobial susceptibility is relatively high. The results show that a hospital patient sputum culture of Respiratory Medicine submission rate, separation rate unchanged from previous years; clinical fungal infections are more serious; bacterial resistance to antimicrobial drugs, the rate is relatively high, especially for penicillin, cephalosporin second and third generation antibiotics The resistance rate is higher; Escherichia coli and Klebsiella acid is produced extended spectrumβ-lactamase main strains, the resistance and non-producing extended-spectrumβ-lactamase producing strains, compared resistance increased significantly.Conclusion1 Department of Respiratory Medicine of a hospital inpatient rate of sputum culture of submission, the isolation rate is low.2 Clinical fungal infections are more serious.3 Present respiratory tract infection pathogens are opportunistic pathogens mainly Gram-negative bacilli.4 For the first few general bacterial susceptibility analysis showed that the majority of bacteria are antimicrobial agents with different degrees of resistance, should be provided as soon as possible check sputum culture, according to the selected antibiotic drug sensitivity test results.5 Treatment of respiratory infectious diseases to anti-inflammatory-based, rational use of antibiotics should be actively regulate the patient's immune defense mechanism to control and delay the bacteria, fungi resistant strains. |
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