Fangjihuangqi Soup Esophageal Cancer Radical Operation On Lung Ischemia Reperfusion Injury In Clinical Research

Purpose:Of traditional Chinese medicine "Fangjihuangqi soup" pre-lung ischemia reperfusion injury of lung protective treatment effect on clinical research of lung ischemia-reperfusion injury and premedication have a meaningful role in guiding for the future of clinical research and exploration new ideas and methods.Materials and Methods:1. Of March 2009 to January 2011 during the first hospital in Wuhan City, Hubei Province,66 patients undergoing radical resection of lung cancer patients who underwent a prospective clinical study pre-medicine. All patients were diagnosed with lung cancer. Age of 40-70 years old, weight 44-72Kg, ASAⅠⅡlevel, preoperative blood, immune, endocrine, neurological and psychiatric diseases, no serious heart, lung, liver, kidney dysfunction, hypertension, coronary heart disease, glaucoma and other complications.66 patients were randomly divided into two groups (n= 33), hereinafter referred to as A group and B group, A group of oral Fangjihuangqi soup group, B group oral 5% glucose control group 2. Premedication:A group of seven days before the start of oral surgery Fangjihuangqi soup, the specific composition and use of herbs as follows:anti-15g has 12g Astragalus Atractylodes 9g 7.5g licorice ginger 4 jujube 1, decoction, take concoction 400ml, Japan 1,2 times taking Shuijianbi, at a pair, a two-clothes; B group in the seven days before surgery began oral 5% glucose injection,200ml, bid.3. After induction of anesthesia, 10min (T1), OLV0.5h (T2), 1h (T3), 1.5h (T4) and after 2h (T5) specimens from a total of five time points measured arterial blood arterial blood gas analysis (U.S. production GEM, STAT portable blood gas analyzer), blood gas index calculations; sacrificing blood 5ml, Determination of serum SOD (superoxide dismutase) activity, plasma MDA (MDA) concentration, parallel PMN (neutral granulocyte number) detection [3].4. Postoperatively stained sections of fixed lung tissue were observed under light microscope alveolar hemorrhage edema.Results:1, General information General information between the two groups was no significant difference, A, B between the two groups compared with each other, P> 0.05.2, blood gas index at each time point:A group of patients undergoing single-lung ventilation in the blood group B was significantly higher than improved (P<0.05).3, SOD, MDA activity and PMN count:A comparative control group at each time point, A group of lower levels of MDA, SOD reduced the P<0.01), slowed the trend of white blood cells increased (P<0.01).4, the postoperative patient biopsy tissue observed under the microscope, A group of lung edema in a significantly reduced compared with group B...