Clinical Analysis Of Infection In Diabetics

[Objective]1.Through the clinic analysis of pulmonary infection,urinary tract infection,skin and soft tissue infection between diabetics and non-diabetics,to further clarify the influence of diabetes to infections diseases.2. To provides the basis for diabetics amalgamative infection early detection and individualized treatment.[Methods]1. The subjects were inpatients between January 2005 in January 2010 in Zhujiang hospital.selected cases with pulmonary infection, urinary tract infections, skin and soft tissue infection in hospital diagnosis cases through the in-patients case retrieval. According to ID ascending arrangement,we take 523 cases at random,including 165 patients with pulmonary infection,202 patients with urinary tract infections,170 patients with skin and soft tissue infection. Meanwhile has two or more site infection have 14 cases. They were divided into two groups:diabetics and non-diabetics.2. A group case-control study was adopted in this research. At home and abroad by reference about diabetic and non-diabetic merger pulmonary infection, urinary tract infection, skin and soft tissue infection to the literature,we have made our In-patients case questionnaire. Researcher obtained information throughconsulting cases of patients, including:ID number, gender, age, history of diabetes, diabetes mellitus type, infection site, infection symptoms, blood white blood count, Pathogen training, antimicrobial susceptibility test, the clinical outcome and hospitalization days.[Results]1.The subjects inculded 364 people in non-diabetic groupand 159 diabetic group.The average hospitalization days in diabetic group was 24.65±19.557days,higher than non-diabetic group (17.75±13.256days).Two and two or more systems infection rate in diabetic group was high (6.3%),and the cure rate in diabetic group was 32.1%.Compared with the control group, both have Statistically significant differences(P<0.001).2. Patients with asymptomatic accounted for 8.2%,higher than non-diabetic group(1.1%). The fever ratio in diabetics was only 17.6%,lower than non-diabetic group(42.0%). The occurrenceof gangrene in diabetics was7.5%,and far more than non-diabetic group(0.3%).Compared with the control group,above all had differences (P<0.001). From 87 patients in diabetic group,57 strains of pathogenic becteria were isolated. From 217 patients in non-diabetic group,106 strains of pathogenic becteria were isolated.The positive rate in diabetic group was higer than non-diabetic group. The pulmonary infection was caused mainly by candida albicans in 2 groups.Escherichia coli were the predominant pathogens in both groups with urinary tract infection,but the percent of Escherichia coli(ESBLs+) was higher in the diabetic group(17.9%)than in the non-diabetic group (9.5%),and mainly sensitive to Cefoperazone Sodium and Sulbactam Sodium.skin and soft tissue infection in diabetics was mainly diabetes foot amalgamative infection. strains from patients who had diabetes foot amalgamative infection were mainly ordinary proteus (30.0%),most sensitive to imine sulfur amphotericin.The resistance to cefazolin was highest.[Conclusions]1. Diabetics have a lower cure rate and a longer hospital stay. Infection systemic poisoning symptoms in diabrtics is not obvious.2. Diabetics when infection occurs are easy diffusion, deterioration.pulmonary infection by two lungs and upper urinary tract infection in diabetics are mainly.Diabetes patients developed skin and soft tissue infection easily gangrene.Diabetes patients developed much site infection increase.3. The positive rate of pathogen cultivate test in diabetic group was higer than non-diabetic group. In this study,the pulmonary infection was caused mainly by candida albicans in 2 groups.Candida albicans generally against fungi drug sensitive. Escherichia coli were the predominant pathogens in 2 groups with urinary tract infection.But drug-resistant proportion in diabetics is elevatory.Diabetes foot infection with the pathogen G coli primarily. Candida albicans the proportion is heavy in diabetics with pulmonary infection, urinary tract infections, skin and soft tissue infection.so to choose sensitive antibiotics or Antifungal drugs,the culture of the urine should be emphasized in diabetics.