The Research Of TXB₂, CRP And Levels Of Glucolipid Metabolism In Patients With Diabetes Complicated By Cerebral Infarction

Objective With diabetes mellitus (DM) the increasing incidence of its complications, especially cerebral infarction and cerebrovascular morbidity increased, so more and more researchers have begun to concern the relationship between DM and cerebral infarction. Therefore, this study was to investigate DM patients with acute cerebral infarction thromboxane B₂ (thromboxane B₂, TXB₂), low-density lipoprotein cholesterol (low-density lipoprotein cholesterol, LDL-C), C-reactive protein (C-reactive protein, CRP) in the Changes, and compared with non-diabetic patients with cerebral infarction, cerebral infarction in diabetes study (DCI) in the pathogenesis and clinical significance of the changes.Methods According to WHO diagnostic criteria for diabetes (1999) and the Fourth National Cerebrovascular Disease Conference established diagnostic criteria (1995), randomly selected from the General Hospital of North China Petroleum 2009-10 to 2010-12 Department of Neurology, 92 patients with cerebral infarction in hospital (Of which 60 cases of cerebral infarction with diabetes, 32 cases of cerebral infarction without diabetes) to the same period the health of the hospital outpatient examination in 30 cases as control group. By double antibody sandwich enzyme-linked immunosorbent assay (ELISA) to detect serum TXB₂ levels. All subjects fasted more than 10 hours after the early morning fasting peripheral venous blood 10ml, immediately sent to the laboratory to take 5ml of serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C ), Low density lipoprotein cholesterol (LDL-C), Apo lipoprotein A1 (APOA1), Apo lipoprotein B (APOB), C-reactive protein (CRP), glycosylated hemoglobin (HbA1c); 5ml venous blood into the rest of ordinary test tubes, for 30 minutes at room temperature after 3500 r / min centrifugation 10min, serum was isolated, placed in -70℃refrigerator temperature, for batch determination of TXB₂ levels. Fasting subjects simultaneous determination of blood glucose (FPG) and 2 hours after breakfast, the day that the blood glucose (2-hPG). All subjects were done in 24 hours after admission head CT scan or MRI.Resultsâ‘´Serum TXB₂ levels: diabetes cerebral infarction, cerebral infarction and normal non-diabetic control group, serum TXB₂ levels were 31.47±3.16 pg / ml, 25.29±4.54 pg / ml, 20.60±3.85 pg / ml, diabetes, cerebral infarction and non-diabetic Cerebral infarction group were higher, the difference was statistically significant ( p<0.05), diabetes, cerebral infarction group than non-diabetic group, the difference was statistically significant ( p<0.05).⑵LDL-C levels: diabetes cerebral infarction, cerebral infarction and normal non-diabetic control group, LDL-C levels were 4.08±0.83 mmol / L, 2.55±0.69 mmol / L, 1.47±0.38 mmol / L, diabetes, cerebral infarction Group and were higher than non-diabetic cerebral infarction, the difference was statistically significant ( p<0.05), diabetes, cerebral infarction group than non-diabetic group, the difference was statistically significant ( p<0.05).⑶CRP level: diabetes cerebral infarction, cerebral infarction and normal non-diabetic control group, CRP levels were 23.97±4.54 mmol / L, 15.15±3.39 mmol / L, 7.22±2.04 mmol / L, diabetes, cerebral infarction and non-diabetic Cerebral infarction group were higher, the difference was statistically significant ( p<0.05), diabetes, cerebral infarction group than non-diabetic group, the difference was statistically significant ( p<0.05).â‘·The expression level of TXB₂ in each group LDL-C, CRP levels were positively correlated, (r were 1.000,0.999, p<0.05). LDL-C and CRP levels were positively correlated (r = 0.998, p<0.05).⑸In diabetic patients with cerebral infarction, lacunar infarction, large areas of infarction, patients with multifocal cerebral infarction was significantly higher than non-diabetics, there was significant difference between the two ( p<0.05).⑹TXB₂, LDL-C, CRP levels were history of diabetes, hypertension, coronary heart disease, HbA1c, FPG, TC, TG were positively correlated with HDL-C were negatively correlated. Three with age, sex, smoking history, drinking history, APOA1, APOB were not correlated.Conclusionâ‘´Diabetes, cerebral infarction group and non-diabetic group TXB₂, LDL-C, CRP levels were significantly higher than healthy controls, including diabetes, cerebral infarction and cerebral infarction than non-diabetic group. Speculated that TXA2 (thromboxane A2. TXB₂ is inactive metabolite), LDL-C, CRP in diabetic vascular complications. Detection of TXB₂, LDL-C, CRP levels may be early large vessels complications of diabetes diagnosis.⑵TXB₂ levels and LDL-C, CRP levels were positively correlated, LDL-C and CRP levels were positively correlated. That TXA2, LDL-C, CRP involved in diabetic vascular complications and the development may have a synergistic effect, expand the sample size to be in the future more in-depth research.⑶TXB₂, LDL-C, CRP level and diabetes mellitus, hypertension, coronary heart disease, HbA1c, FPG, TC, TG were positively correlated with HDL-C was negatively correlated, suggesting that the long- Of hypertension, hyperglycemia, dyslipidemia promote the occurrence of diabetic macroangiopathy.