Relationship Between Nasal Polyps And Human Papillomavirus Subtypes

Objective To study the distribution of HPV subtypes in the nasal polyps, and to evaluate the relationship between HPV and nasal polyps.Methods 37 HPV subtypes were detected in paraffin-embedded tissues of 204 cases of nasal polyps by flow through hybridization and gene chip (HybriMax) and 36 cases of normal nasal mucosa were used as controls.Results HPV infection was prevalent in patients with nasal polyps as significant promoted HPV infection was found in the nasal polyps tissues from 82 of 204 (40.2%) patients (P < 0.05 compared with healthy control). Genotyping analysis showed that LR-HPV-11 was the most prevalent type (45.28%). Both single- and multi-HPV genotype infections existed in the HPV-positive samples, and most of the cases (74.39%) were infected with single HPV genotype. However, patients'gender, age, number of operations, and disease course were not correlated with HPV infection or HPV subtypes.Conclusions Our present results indicated that the occurrence and development of nasal polyps was closely related with HPV infection. Both high risk-HPV (HR-HPV) and low risk-HPV (LR-HPV) genotypes were identified in nasal polyps tissues, and LR-HPV-11 was the most prevalent type.