Study On Relationship Between TNF-α,CRP In Peripheral Blood And Acute Coronary Syndrome With Different Glucose Tolerance

object: To provide new appreciating standards for interfering acute coronary syndrome with different glucose tolerance and TNF-α,CRP in peripheral blood.Methords: 148 inpatients with acute coronary syndrome were enrolled from January of 2009 to June of 2010. These patients were divided into three groups. (1) Control group-normal glucose tolerance (NGT), including 50 patients, fast glucose <5.6mmol/L,OGTT 120min blood glucose<7.8 mmol/L; (2) Injuried glucose tolerance group (IGT), also including 50 patients, fast glucose<5.6mmol/L, OGTT,7.8 mmol/L<120min blood glucose<11.1 mmol/L; (3)Type 2 of diabetes group (T2DM), including 48 patients, fast glucose>7.0mmol/L and/or OGTT 120min glucose> 11.1 mmol/L. No significant difference lie in age, sex, body weight among the three groups. TNF-a and hs-CRP were tested by ELISA. Coronary Angiograph was done in all patients. Statistical analysis was done by SPSS13.O. Eliminating standards include tumor, anti-inflammatory agents in recent use, infectious disease, autoimmune disease, hepatopathy, disorder in kidney, bleeding in digestive tract, recent serious trauma and operation et al.Results:1. TNF-a and CRP were significantly elevated in IGT and T2DM groups compared with NGT group (all P<0.01).2. TNF-a and CRP are high in T2DM group compared with IGT group, however no significance is found between the two groups.3. TNF-aand CRP are positively correlated with HOMA-IR respectively (r:0.376,0.384, both P<0.01). TNF-a is positively correlated with CRP (r:0.291, P<0.01)Conclusion:1.More serious inflammation and unstable plaques occured in ACSs with T2DM and IGT compared ACSs with NGT.2.Insulin resistance was the main factor for unstable plaques and played an important role for the presence of ACS.3.The correlation between TNF-aand CRP demonstrated that the two factors co-induced, cooperated and promote the occurrence of ACS.