Influence Of Low Pressure Hypoxia On Contents Of Seven Types Of Microelement In Rats

Objective To study the effects of low pressure hypoxemia on contents of Zn, Cu, Cr, Fe, Co, Ni and Mn in main organs and serum of rats.Methods Sixty of Wistar rats were divided into the control group, experimental group I and experimental groupⅡ, and 20 of rats with half of male and female were in each group. The rats in the experimental groups were placed into the hypobaric chamber, they were simulatedly ascended to 7 km high at the speed of 20m/s. This action lasted for 1.5h once a day. The sample of blood and main organs was collected at tenth day in experimental group I and at twentieth day in experimental groupⅡand the content of Zn, Cu, Cr, Fe, Co, Ni and Mn in the sample was detected by atomic absorption.Results Compared with the control group, in the experimental groupⅠ, the content of Fe obviously decreased in brain, livers and serum(P<0.01), while it increaseed apparently in hearts and lungs(P<0.01); the content of Cu increased in lungs(P<0.01), the content of Ni increased in kidneys and lungs (P<0.01), while it decreased in livers(P<0.01), and the content of Mn increased(P<0.01). The content of Zn decreased in kidney(P<0.05), and so did Zn in serum(P<0.01), while the content of Cu in serum and Cr in lung largely increased(P<0.05), and so did Cu in spleen.Compared with the control group, in the experimental groupⅡ, the content of Fe obviously increased in hearts, kidney and lungs (P<0.01), while it decreased in livers and serum(P<0.01); the content of Cu increased in brain, hearts and lungs(P<0.01), the content of Ni increased in lungs (P<0.01), the content of Mn increased in livers and serum(P<0.01). The content of Zn apparently decreased in brain, kidney and serum(P<0.01), while the content of Zn in lung and Cu in serum increased (P<0.05); and this phenomenon is more apparently existed for the content of Cu in brain(P<0.01). Compared with the experimental groupⅠ, in the experimental group II, the content of Fe decreased in brain, lungs and serum(P<0.01), while it increased in kidneys (P<0.01); Co increased in lungs and brain(P<0.01), Ni in kidneys decreased significantly (P<0.01), while it increased in lungs(P<0.01). The content of Cu increased in brain and lung (P<0.01), but declined in heart and kidney(P<0.01). The content of Cr increased in kidney and lung (P<0.01).Conclusions Low pressure hypoxia lead to content of Zn,Cu,Cr,Fe,Co,Ni and Mn in rats changed significantly in the main organs and serum, the increase of Fe, co, Ni and Mn are helpful to adapt to hypoxia stress.