Expression And Clinical Significance Of VEGF-C And MMP-9 In Colorectal Cancer

Objective:To study the expression and clinical significance of VEGF-C and MMP-9 in colorectal cancer with tissue microarray, then the roles such factors played in the oncogenesis and metastasis will be explored.Methods:We built one colorectal cancer tissue ship with tissue microarray technique, which including 60 cases of colorectal cancer tissue and 20 cases of adjacent normal tissue.By using immunohistochemistry, the expression of VEGF-C and MMP-9 was detected. Then we got the information on the different expressions of colorectal cancer tissues and adjacent normal tissues, as well as the colorectal cancer tissues with different clinical stages.With the help of statistical software, the relevance of VEGF-C and MMP-9 was analyzed.Results:First, the positive rates of VEGF-C and MMP-9 in colorectal cancer tissue were 85.0%(51/60) and 80.0%(48/60) respectively, while they were 5.0 %(1/20) and 10.0%(2/20) in adjacent normal tissue. The expressions of them were significantly higher in colorectal cancer tissue than adjacent normal tissue (P<0.05). Senond, we divided such 60 cases of colorectal cancer tissue into differernt clinical stages, and in Dukes A and B,the positive rate of VEGF-C was 74.2%(23/31), while it was 96.6%(28/29) in Dukes C and D stage. The expression was significantly higher in Dukes C and D stage than Dukes A and B stage of colorectal cancer (P< 0.05). Third, in such 60 cases of colorectal cancer tissue, the positive rates of MMP-9 in Dukes A and B stage and Dukes C and D stage were 67.7%(21/31) and 93.1% (27/29) respectively. The expression was significantly higher in Dukes C and D stage than Dukes A and B stage of colorectal cancer (P<0.05). Fourth, after statistical analysis, the positive expression of VEGF-C was significantly consistent with MMP-9 (rs=0.842, P<0.05) in colorectal cancer tissue.Conclusion:First, the expression of VEGF-C and MMP-9 were significantly higher in colorectal cancer tissue than adjacent normal tissue,and the later of the clinical stage,the higher of the expression. The expression of them was significantly consistent with the oncogenesis and metastasis of colorectal cancer. Second, the positive expression of VEGF-C was significantly consistent with MMP-9 in colorectal cancer tissue, detecting them together will improve the early diagnosis and treatment, as well as the evaluation of the prognosis for colorectal cancer patients.