Mechanism Of Hyperthyroidism Patients Combined With Abnormal Glucose Metabolism Study

Objective:The rate of abnormal glucose metabolism is high in hyperthyroidism patients. But how high and its possible mechanism remain unclear. We sponsor this study to investigate the rates of glucose disorder, the changes of some hormones and cytokines and analysis the possible mechanism.Methods:All the patients enrolled underwent oral glucose insulin releasing test (OGIRT) to determinate the plasma glucose and insulin levels at Omin,30min,60min,120min,180min of 75 g glucose. The area under the curve of glucose (AUCG),area under the curve of insulin(AUC1),insulin sensitivity index (ISI) insulin resistance index(HOMA-IR),insulin secretion index (HOMA-IS) were calculated.The fast leptin,adiponectin,IL-1α(interleukin-1α),IL-2 IL-6 were also detected. Then, the patients were divided into "normal glucose tolerance"group and "abnormal glucose tolerance"group according to the results of OGIRT. Their thyroid function were compared between these two subgroups. A health control group also underwent all above procedure. The indices of health control and hyperthyroidism were compared, too. Analyse the relationship between abnormal glucose metabolism and thyroid antibodies.Results:(1) The incidence of glucose metabolic disorders in hyperthyroidism group was as high as 53.5% in our research, and diabetes reached 18.6%, was distinctly higher than normal control.(2) AUCG of hyperthyroidism group was significantly higher than that of control group(P<0.01), AUC1 between two groups were no statistical significance(P>0.05).(3) ISI of hyperthyroidism group was significantly lower than that of control group (P<0.01), HOMA-IR was significantly higher (P< 0.01), and HOMA-IS was also significantly higher (P<0.01; than that of control group. (4)There is no statistical significance of thyroid function between"normal glucose tolerance"group and "abnormal glucose tolerance"group (P>0.05).(5) The fast leptin,adiponectin,IL-1αIL-2,IL-6 were also of no significance(P> 0.05).(6)There is no significance of insulin resistance between different thyroid antibodies levels.Conclusion:The glucose metabolic disorders in hyperthyroidism are as high as 53.5%. The area under the curve of glucose (AUCG) of hyperthyroidism group was significantly higher than that of control group while the area under the curve of insulin (AUC1) between two groups were no statistical significance, suggests that hyperthyroidism patients have insulin resistance rather thanβcell dysfunction.