TCM Essential Hypertension And UA, Urinary MALb, Blood And Urine β2-MG Correlation

Objective:To investigate the relevancy of TCM syndrome type primary hypertension with uric acid, mALb, blood and urineP2-MG, and the relationship of uric acid and mALb,β2-MG,apply the clinical observation evidence for the prevention and treatment of hypertension in the provision of early renal injury.Methods:120 patients were included in this study that fit the diagnostic criteria of Western medicine for patients with hypertension, according to TCM diagnostic criteria for syndrome differentiation. All the patients were fasting for 12 hours, the vein blood and the urine specimens were collected in the next morning for the same time.Detet the serum creatinine (Cr), blood urea nitrogen (BUN) and urinary albumin (mAlb), blood and urine (32-microglobulin (β2-MG), serum uric acid (UA).And analyse the relationship of the serum UA and urine mALb, blood and urineβ2-MG.Results:①There was no evident statistic difference between men and women in incidence of HUA(P>0.05).②There was no statistic difference among different blood pressure levels in UA (P>0.05).According to the mean,UA increased with the increase of blood pressure.③There was no statistic difference between HUA group and NUA group in urinary mALb, blood and urineβ2-MG(P>0.05).④There was no significant correlation between UA and urine mAlb, urinary and bloodβ2-MG(P>0.05).⑤There was statistically significant difference between HUA group and NUA group in Cr and BUN (P<0.05),and the level of Cr and BUN in HUA group was higher than that of NUA group.⑥There was not statistic difference between HUA group and NUA group in TC, TG, HDL,and LDL(P>0.05).According to the mean, the levels of TC, TG and LDL in HUA group were significantly higher than that of NUA group.⑦The analysis of the correlation between UA and TC, TG, HDL, LDL:there was no significant correlation between UA and TC,LDL(P>0.05);there was evident correlation between UA and TG,HDL(P<0.05);there was positively correlation between UA and TG;there was negatively correlation between UA and HDL.⑧There was no significant difference in UA among the hypertension groups of the four syndromes(P>0.05).Pairwise comparison:There was statistic difference between hyperactivity group and phlegm dampness group(P<0.05).Compared phlegm dampness group with the yin and yang,there was statistic difference (P<0.05).Based on the mean level of UA,the level of deficiency of both yin and yang was highest,followed by hyperactivity, anger hyperactivity, phlegm dampness.⑨There was no statistic difference in Cr,BUN among the four syndromes(P>0.05).⑩There was no statistic difference urinary mAlb among the four syndromes(P>0.05).Among the four syndromes, the difference in Urineβ2-MG was statistically significant (P<0.05).Based on the mean rank of each group,the descending order was:yin and yang> hyperactivity> phlegm dampness> anger Kang Sheng.There was significantly different in serumβ2-MG among the four syndromes(P<0.05).Based on the mean rank of each group, the descending order was:yin and yang>hyperactivity>phlegm dampness> anger hyperactivity.Conclusion:①The elevated level of serum uric acid correspond to hypertension syndromes consistent with the evolution of law. With the progression of hypertension, yang was more serious than yin.②The results point out that there is on relevance between UA and urine mAlb,β2-MG in urine and blood,it needs to be observed in the future.③Many patients with hyperuricemia have lipid metabolism, which is closely related with triglycerides.④Blood and urineβ2-MG levels correspond to evolution of hypertension syndromes, reflecting the different hypertensive renal damage level and location, the detection ofβ2-MG in blood and urine have guiding significance for the treatment and prognosis of hypertension.