Clinical Therapeutic Efficacy With Huangqizhimushenqi Granula For Diabetic DKD The Third Stage With Qi And Yin Vacuity

Objective:To observing the changes of Cystatin C(CysC)β2-microglobulin(β2-MG),24h urine protein (UP-24), serum C-reactive protein (CRP) levels,as well as diabetic retinopathy (DR) the change "Huangqizhimushenqi Granula" diabetic kiDKDey disease (DKD) the 3rd stage with qi and yin vacuity, the clinical efficacy and to explore its possible mechanism of DKD; with a view to DKD early prevention and treatment of renal dysfunction in patients with DKD slow progress in reducing the duration and in patients with DKD 5th stage into the replacement treatment.Methods:Select treatment in Hospital, Department of Nephrology, Department of Endocrinology, and Chinese medicine outpatient clinic of the Qi and Yin vacuity the 3rd stage DKD 60 patients were randomly divided into control groups with 30 patients and treatment group of 30 patients treated with Huangqizhimushenqi Granula in the control group to the conventional Western medicine treatment to 8 weeks as a course of treatment, were observed therapy Qi and Yin vacuity the 3rd stage DKD, the clinical efficacy and CysC,β2-MG, UP-24, CRP levels and DR.Results:(1) groups before and after treatment the clinical symptoms of traditional Chinese medicine. treatment group was more effective than the control group (p<0.05). The treatment group response rate was 96.7% while the control group response rate was 80%. (2) The two groups after treatment than before treatment serum CysC significantly improved (p<0.05), lower levels of the treatment group than in the control group had significant differences. (3) After treatment, the level ofβ2-MG were significantly improved (p<0.05), but the treatment group compared with the control group no significant difference (p> 0.05). (4) After treatment, two UP-24 levels were significantly improved (p<0.01), and the treatment group compared with the control group with significant difference (p<0.01). (5) CRP levels after treatment both groups were significantly improved (p<0.05), but the treatment group compared with the control group no significant difference (p> 0.05). (6) DKD generally associated with the occurrence of DR, DR situation improved significantly after treatment (p<0.05), the treatment group was 87% in the control group response rate was 82.6%. The therapeutic effect was no significant difference (p>0.05). (7) inadvertently during treatment, liver and kiDKDey dysfunction, no electrolyte imbalance. Conclusions:(1) After treatment, clinical symptom score, UP-24, CRP, Fib, and DR conditions better than those before treatment. (2) groups of UP-24, CRP, Fib difference before and after treatment there is significant correlation. (3) instructor experience side, Huangqizhimushenqi Granula " treatment Qi and Yin vacuity DKD 3rd stage, can significantly alleviate the symptoms, signs, can significantly improve its curative effect, the use of safe, non-obvious side effects, it is worth popularization and application.