Epidemiological Study Of Helicobacter Pylori Infection And Its Related Factors In Shenzhen Residents Undergoing Physical Examination

Objective To explore the Helicobacter pylori(H.pylori) infection status in Shenzhen city residents undergoing physical examination and its related factors.Methods A total of 3856 Shenzhen inhabitants, who were examined by the medical examination center or VIP center of our hospital between March 2008 and July 2009 ,were included in this study. H.pylori infection was assessed by 13C-urea breath test(UBT)or 14C-urea breath test,and data were collected by using a standard questionnaire,involving general conditions,family environment, personal habit,diet habit.Results The total rate of H.pylori infection was 49.7% in Shenzhen residents undergoing physical examination, and 50.9% in the males ,and 48.2% in the females. The infection rate was not different in different administrative areas.The infection rate was different in different age groups,was the lowest in the age group of <10(19%),was increased significantly to 40.6% in the age group of 10~20,and gradually become higher,and the highest(58.3%)in age group of 60~70,but become lower in the group of >70.The infection rate was 42.6% in the group who lived in Shenzhen less than one year,which was remarkably lower than the general infection rate of Shenzhen(P<0.01),but the infection rate went up to the general infection rate after one year.The infection rate of the loss of spouse ,the married or cohabitation was respectively 58.3% and 52.4% , which were remarkably higher than the singlehood ,the divorced or the separated(P<0.01). The infection rate of the persons whose spouse was illiteracy was very high (77.8%),which was remarkably higher than others(P<0.05).The infection rate of the persons who didn't have spouse was the lowest(44.1%).The H.pylori infection rate of medical staff,civil servant,teacher was respectively 66.2%,54.7%,63.2%,which was remarkably higher than other occupations(P<0.01). The infection rate of the persons who used to drink river water was remarkly higher than the one who have been used to drink other water resources(P<0.01),H.pylori infection rate was decreased significantly in subjects who drank purified water(46.0%).The prevalence rate of H.pylori infection was low in subjects who always ate raw vegetables and fruits(44.9%).The infection rate was different between alcohol drinking and non-alcohol drinking(52.5% VS 47.7%,P<0.05),but negatively correlated with the time limit and frequency of alcohol drinking. Multivariate logistic regression analysis showed that, H.pylori infection was positively associated with age and alcohol drinking,but negatively associated with eating raw vegetables and fruits.Conclusion The total rate of H.pylori infection was 49.7% in Shenzhen residents undergoing physical examination. The infection rate was not different between the males and the females. The infection rate was not different in different administrative areas.The infection rate was different in different age groups. There were associations between the time living in Shenzhen, marriage status, occupation, educational background of the spouse, water resources, eating raw vegetables and fruits, alcohol drinking and H.pylori infection.