A Study On The Association Of The Polymorphisms Of MBL Genes With Susceptibility To Tuberculosis In Xinjiang Hans

Objective:To explore the association between the genetic polymorphism of MBL and susceptibility to pulmonary tuberculosis in Xinjiang Han population.Methods:A case-control study was conducted,chosing 231 XinJiang Han patients with tuberculosis from Ta and Shihezi cities to be genotyped for H/L,P/Q and A/B SNPs in MBL gene by using the sequence-sp-ecific polymerase chain reaction (PCR-SSP).Gene frequency (f) and odds ratio (OR) were calculated and c-ompared with those of 226 healthy individuals from the same areas.Using the SPSS 13.0 to analyze the difference of the frequency of MBL three alleles and haplotype between the two groups.Chosing Chi-squar-e test or Fisher's exact test to analysis the association between alleles and tuberculosis.Result:The frequency of MBL-AA homozygote genotype in the group with tuberculosis disease is 74.03%,and it is significantly lower than 82.30% in the group of control in XinJiang hans.The significant difference is remained after the two group being tested (x2=4.576, P=0.032<0.05,OR=0.613); but the freuqency of MBL-AB homozygote genotype in the case group is 24.68%,it is significantly higher than 16.37% in the control group,the significant difference is also remained after the two group being tested(x2= 4.821, P=0.028<0.05, OR=1.673);but the freuqencies of genotypes and haplotypes in MBL-H/L,P/Q SNPs had no statistically difference between the case and the control groups(P>0.05).Conclusions:1.The results showed that MBL-AA homozygote genotype is probably a protective gene in tuberculosis for Xinjiang Han population;2. The results showed that MBL-AB homozygote genotype may be a susceptible gene in tuberculosis for Xinjiang Han population;3. No evidences supported that the genotypes and haplotypes in MBL-H/L,P/Q SNPs were associated with tuberculosis for Xinjiang Han population.