Expression Of TopoⅡ And GST-π In Gasteric Cancer And Colorectal Carcinoma

Objective:To investigate the clinical significance and expression of topoisomerase(Topo II)and glutathione-s-trannsferase(GST-π) in gastric cancer and colorectal carcinoma.Methods:The expression of TopoIIand GST-πin 40 cases of gastric cancer and 60 cases of colorectal carcinoma was detected by immunohistochemical technique. its correlation with clinical pathologic characteristic of gastric cancer and colorectal carcinoma, including histological type, invasion degree and lymph node metastasis was explored as well.Results:(1) Of 40 cases of gastric cancer, the positive expression rates of Topo Hand GST-πwere 42.5% and 82.5, respectively, The expression rate of TopoⅡin well- moderated differentiation adenocarcinoma was lower than that in poor differentiation adenocarcinoma(P<0.01), The expression rates of GST-πin well-moderated differentiation adenocarcinoma were significantly higher than those in poor differentiation adenocareinoma(P<0.01), but not'with other pathological characteristics studie. (2) The positive rates of Topo Hand GST-πin colorectal carcinoma tissue were 43.3% and 93.3%, respectively, There were no corelation between overexpression of TopoⅡand GST-πand pathological characteristics studied in colorectal carcinoma.Conclusion:TopoⅡand GST-πplay important roles in the primary MDR of gastric cancer and colorectal carcinoma. The determination of TopoⅡand GST-πmay be useful for the estimatation of prognosis and the establishment of chemical therapy regimen in gastric cancer and coloctal carcinoma.