2 - 1 - (4 - Pyridyl) Ethoxy Acetic Acid Esters Synthesis Of Learning And Memory In Mice Role

Aim:Synthesize the 2-(1-(pyridine-4-yl) ethoxy) acetate derivatives, and discuss these compounds'effects of learning and memory facilitation in mice. Methods:4-(1-bromoethyl) pynidine (2) was obtained by 4-ethylpyridine (1) through Whol-ziegler reaction with NBS. Ethyl [2-1-(pyridine-4-yl) ethoxy)] acetate (3) was obtained by (2) through Williamson reaction with sodium 2-ethoxy-2-oxo-ethanolate. Compound 3 reacted with all kinds of alchol to get compounds 4a-41,5a-5g., respectively. The effects of compounds on learning and memory in mice were tested by water maze test. Results:We designed and synthesized 20 new c impounds, and the structures of the compounds were confirmed by IR,1H-NMR spectrum. The pharmacological results showed that 2-(dialkylamino) ethyl-2-(1-(pyridin-4-yl) ethoxy) acetates have good learning and memory facilitation in mice.