Screening The Active Site Of Hance On The Treatment Of Cardiovascular Disease

Ixeris sonchifolia,as compositae familiay dried whole plant of the year.With the continuous progress of clinical application, Ixeris sonchifolia preparation in modern research of Chinese medicine is increasingly being recognized by the people. The clearing and detoxifying, the abscess, analgesic effect. Clinically in the treatment of coronary heart disease, cerebral infarction and other diseases of the effect is significant. Hance has a variety of pharmacological activities, very development value, but its ingredients is relatively complex, the pharmacological effect of the active ingredient and the synergies between the various components continued to show a lack of research. Ixeris sonchifolia flavonoids as the main active ingredient, luteolin and its glucoside were higher. It has strong antioxidant activity, the pharmacological activity and clinical trial results also showed that in vivo have antibacterial, antiviral, and reduce blood fat and cholesterol.In this study, we use the organic solvent extraction method to extract Ixeris sonchifolia, and use silica gel chromatography and high performance liquid chromatography to examin its contents.Through the establishment of rat model of myocardial infarction, we analyse the mechanism in the total flavonoids which is effective part of Ixeris sonchifolia on myocardial ischemia and other cardiovascular diseases related to.Filtering out of this or these components combined with modern pharmacology and chemical means to strengthen the active ingredients of the new screening and confirmation, provide the basis for the development of new drugs.