Study On The Correlation Between Serum Cystatin C And TCM Syndromes Of Diabetic Kidney Disease

Objective:Studying on TCM syndromes of diabetic kidney disease and the determination of serum Cys C,the purpose is to approach the distribution rule of the TCM syndromes,to approach the correlation between TCM syndromes and serum Cys C,to provide some initial micro index for determining the treatment based on differentiation of symptoms and signs of traditional chinese medical in clinic.Methods:100 patients with DKD were collected according to the inclus--ion and exclusion criteria in our hospital.Record the patients'symptoms by using the designed information-collecting table.According to diagnostic criteria of TCM symptomes,patients were typification, before inviting three attending physicians to make sure the diagnosis.Research the relationship between the TCM symptomes and serum Cys C.Results:l.The distribution characteristics of the principal syndrome in 100 case of patients with DKD were as follows:13 cases of yin asthenia and dryness--heat syndrome,accounting for 13%;31 cases of two qi and yin deficiency syndrome,accounting for 31%;42 cases of qi-deficiency of the spleen and kidney type,accounting for 42%; 14 cases of yin-yang deficiency syndro-me,accounting for 14%.The distribution characteristics of the subordinate syndrome in 79 case of patients with DKD were as follows:25 cases of damp-heat syndrome,accounting for 31.65%;6 cases of cold-dampness syndro e,accou ntting for 7.59%;38 cases of stasis syndrome,accounting for 48.10%;10 cases of phlegm-stasis syndrome,accounting for 12.66%.2.Comparing the ages of each TCM principal syndromes,yin-yang deficiency syndrome in DKD patients is the highest;the syndrome of qi-deficiency of the spleen and kidney and the syndrome of two qi and yin deficiency are lower than syndrome of yin-yang deficiency;yin asthenia and dryness-he'at syndrome is the lowest.The discrepancy between qi-yin deficiency group and qi-deficiency of the spleen and kidney type has no statistical significance(P=0.20207>0.05).Comparing the ages of each subordinate TCM syndromes,the syndrome of cold-dampness and syndrome of phlegm-stasis in DKD patients is the highest;the syndrome of damp-heat is lower than cold-dampness syndrome and phlegm-stasis syndrome;stasis syndrome is the lowest.The discrepancy between cold-dampness syndrome and phlegm-stasis syndrome has no statistical significance(P=0.9>0.05);the discrepancy between damp-heat syndrome and stasis syndrome has no statistical significance(P=0.42>0.05).3.There was no significant difference with regard to sex distributing eig--ht syndromes(P<0.05).4.Judging from the primary course of DKD patients,along with the increase of the primary course,the principal syndrome types developed from yin asthenia and dryness-heat syndrome and to qi-yin deficiency syndrome and to qi-deficiency of the spleen and kidney type and to yin-yang deficiency syndrome;the differences between the four TCM syndromes have statistical significances(.P<0.05,.P<0.01).Along with the increase of the primary course,the subordinate syndrome types developed from stasis syndrome to damp-heat syndrome and to phlegm-stasis syndrome and to cold-dampness syndrome;the difference between the phlegm-stasis syndromes and cold-dampness syndrome has no statistical significance(P>0.05).5.The trend of serum Cys C,Scr and BUN is control group<yin asthenia and dryness-heat group<qi-yin deficiency group<qi-deficiency of the spleen and kidney type group< yin-yang deficiency group.The difference of serum Cys C between control group and yin asthenia and dryness-heat group has no statistical significance(P>0.05).The difference of Scr and BUN between yin asthenia and dryness-heat group and control group has no statistical significance(P>0.05),and the difference of Scr and BUN between yin asthenia and dryness-heat group and qi-yin deficiency group has no statistical significance else(P>0.05).The trend of serum Cys C,Scr and BUN is control group<stasis syndrome group<damp-heat group<phlegm-stasis group<cold- -dampness group,and the differencs between cold-dampness group, phlegm--stasis group and damp-heat group have no statistical significance(P>0.05).Conclusion:1.The DKD patients'distribution about TCM syndromes was the most in the qi-deficiency of the spleen and kidney type,two qi and yin deficiency syndrome,stasis syndrome and damp-heat syndrome.2.The DKD patients'distribution about TCM syndrome has nothing to do with sex.3.Along with the increase of age of patients with extended and rising serum Cys C levels,the principal syndrome types developed from yin asthenia and dryness-heat to qi-yin deficiency syndrome and to qi-deficiency of the spleen and kidney type and to yin-yang deficiency syndrome,the subordinate syndrome types developed from stasis syndrome to damp-heat syndrome and to phlegm-stasis syndrome and to cold-dampness syndrome.4.Along with the increase of serum Cys C, Scr and BUN,the principal syndrome types developed from yin asthenia and dryness-heat,qi-yin deficiency syndrome to qi-deficiency of the spleen and kidney type,yin-yang deficiency syndrome;the subordinate syndrome types developed from stasis syndrome to damp-heat syndrome,phlegm-stasis syndrome and cold-dampness syndrome.The Serum Cys C increase by dialectic styles in TCM.Serum Cys C is more relatived with TCM syndromes of diabetic kidney disease than Scr and BUN,especially in the early diabetic kidney disease,so it can be a micro theory basis of TCM syndromes of diabetic kidney disease.