The Effect Of Intensive Station On Myocardium In Acute Coronary Syndrome Patients Underwent Percutaneous Coronary Intervention

Objective:The aim of the study was to apply the intensive treatment for acute coronary syndrome (ACS) patients underwent percutaneous coronary intervention (PCI) and observe the changes of plasma creatine kinase isozyme (CK-MB), troponin I (CTnI), high-sensitive c-reaction protein (hs-CRP), creatine kinase (CK), serum lipids. And also explored the effects and safety of intensive statin treatment for myocardium in ACS patients and discuss the mechanisms.Method:112 ACS patients were randomly divided into two groups. Patients in intensive treatment group (54) took 80mg atorvastatin 12 hours before PCI and took 40mg/d atorvastatin for 30 days after PCI. Patients in routine group (58) took 20mg/d atorvastatin before and after PCI for 30 days. Other treatment were given according to guideline including thrombolytic agents, anticoagulant, ACEI, calcium channel antagonists, nitrate or other conventional drugs, the plasma 1 evels of CK-MB, CTnI, hs-CRP,CK, serum lipids were measured 12 hours before PCI,24hours and 30 days after PCI.Results:1. The patients in intensive treatment group had a lower incidence of 1ULN (upper limits of normal) and 3ULN CK-MB, CTnl. the comparison between two groups had statistical significant(P<0.05).2. Compared to the routine group, the intensive group had a lower level of serum hs-CRP 24 hours and 30 days after PCI. The comparison between groups had statistical significant (P<0.05).3. The changes of serum lipids 24 hours after PCI between two groups were statistically no significant (P>0.05). After 30 days'treatment, the serum lipids in two groups were both decreased. The intensive group had a lower level of Total Cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) than the routine group (P<0.05).Conclusion:1. Intensive therapy can reduce the incidence of myocardium injury and myocardium infarction.2. Intensive therapy can reduce the levels of hs-CRP 24 hours and 30 days after PCI. Intensive statin therapy has anti-inflammatory effects in short-time and long-term treatment.The short-term effects of protection for myocardium are relevant to anti-inflammatory and other mechanism, with little relation with lipid-lowering effect. The long-term protective function should be relevant to the anti-inflammatory, lowering serum lipids and other mechanism.3. Intensive therapy treatment for Chinese patients underwent PCI is safe. But more studies should be needed.